Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Cancer Immunology Program, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Nat Cancer. 2023 Aug;4(8):1083-1094. doi: 10.1038/s43018-023-00602-2. Epub 2023 Jul 31.
The intersection of the microbiota and cancer and the mechanisms that define these interactions are a fascinating, rapidly evolving area of cancer biology and therapeutics. Here we present recent insights into the mechanisms by which specific bacteria or their communities contribute to carcinogenesis and discuss the bidirectional interplay between microbiota and host gene or epigenome signaling. We conclude with comments on manipulation of the microbiota for the therapeutic benefit of patients with cancer.
微生物组与癌症的交汇点以及定义这些相互作用的机制是癌症生物学和治疗学中一个引人入胜且快速发展的领域。在这里，我们介绍了最近对特定细菌或其群落促进癌变的机制的深入了解，并讨论了微生物组与宿主基因或表观基因组信号之间的双向相互作用。最后，我们对操纵微生物组以造福癌症患者的治疗益处发表了评论。
