Çavuşoğlu Türker Betül, Ahbab Süleyman, Türker Fatih, Hoca Emre, Çiftçi Öztürk Ece, Kula Atay Can, Öztürk Hüseyin, Urvasızoğlu Ayşe Öznur, Bulut Merve, Yasun Özge, Ataoğlu Hayriye Esra
Department of Internal Medicine, University of Health Sciences, Haseki Health Training and Research Hospital, İstanbul, Turkey.
Internal Medicine Department, Ivrindi State Hospital, Balıkesir, Turkey.
Int J Gen Med. 2023 Jul 26;16:3163-3170. doi: 10.2147/IJGM.S420332. eCollection 2023.
Internal medicine services serve the patient population with many chronic diseases. Therefore, it is high mortality rates compared to other departments of the hospital. Estimating the prognostic risk of hospitalized patients may be useful in mortality for patients. İn this study, we evaluated the level of Systemic Immune Inflammation Index (SII) and Systemic Inflammation Response Index (SIRI) and its association with mortality in inpatients.
This study was performed in 2218 patients who were hospitalized between January 1st-December 31th of 2019. Patients were followed up for three years about primary endpoint as all-cause (except for unnatural deaths) mortality. Participants were divided into 4 equal groups according to their increasing levels of SII and SIRI. (Quartile 1-4) Age, gender, diabetes mellitus, hypertension, coronary artery disease, chronic kidney disease, malignancies (solid), white blood cell, neutrophil, lymphocyte, monocytes, hemoglobin, hematocrit, platelet, CRP, albumin, Systemic Inflammation Response Index (Quartile 1-4), Systemic Immune Inflammation Index (Quartile 1-4) were compared between survival and non-survival groups.
There were 1153 female and 1065 male participants enrolled. Compared with surviving patients, patients who died were older and had a higher prevalence of diabetes mellitus, hypertension, malignancy, chronic kidney disease and coronary artery disease (p < 0.001). There was a lower proportion of female patients among the patients who died. Compared to the survivor group, group who died exhibited a significant increase in CRP level, neutrophil, white blood cell and monocyte counts, but had a lower lymphocyte count, albumin level and hemoglobin count (P < 0.001). Results of Cox regression analysis showed that age, chronic kidney disease, malignancy, SIRI quartile 3, 4 and SII quartile 3, 4 pointed out a close relationship with mortality risk. (P < 0.001).
The SIRI and SII have indicated the clinical importance of as novel markers for predicting mortality in inpatients.
内科服务的对象是患有多种慢性病的患者群体。因此，与医院的其他科室相比，其死亡率较高。评估住院患者的预后风险可能对患者的死亡率预测有所帮助。在本研究中，我们评估了全身免疫炎症指数（SII）和全身炎症反应指数（SIRI）水平及其与住院患者死亡率的相关性。
本研究纳入了2019年1月1日至12月31日期间住院的2218例患者。以全因（非自然死亡除外）死亡率作为主要终点，对患者进行了三年的随访。参与者根据其SII和SIRI水平的升高分为4个相等的组（四分位数1 - 4）。比较了生存组和非生存组之间的年龄、性别、糖尿病、高血压、冠状动脉疾病、慢性肾脏疾病、恶性肿瘤（实体瘤）、白细胞、中性粒细胞、淋巴细胞、单核细胞、血红蛋白、血细胞比容、血小板、CRP、白蛋白、全身炎症反应指数（四分位数1 - 4）、全身免疫炎症指数（四分位数1 - 4）。
共纳入1153名女性和1065名男性参与者。与存活患者相比，死亡患者年龄更大，糖尿病、高血压、恶性肿瘤、慢性肾脏疾病和冠状动脉疾病的患病率更高（p < 0.001）。死亡患者中女性患者的比例较低。与存活组相比，死亡组的CRP水平、中性粒细胞、白细胞和单核细胞计数显著升高，但淋巴细胞计数、白蛋白水平和血红蛋白计数较低（P < 0.001）。Cox回归分析结果显示，年龄、慢性肾脏疾病、恶性肿瘤、SIRI四分位数3、4和SII四分位数3、4与死亡风险密切相关（P < 0.001）。
SIRI和SII已表明作为预测住院患者死亡率的新型标志物具有临床重要性。
