Ding Kaixi, Jiang Wei, Zhangwang Juejue, Wang Yu, Zhang Jing, Lei Ming
School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
Naunyn Schmiedebergs Arch Pharmacol. 2023 Dec;396(12):3483-3501. doi: 10.1007/s00210-023-02639-7. Epub 2023 Aug 1.
Sarcopenia is a major global public health problem that harms individual physical function. In 2018, the European Working Group on Sarcopenia in the Elderly 2 classified sarcopenia into primary and secondary sarcopenia. However, information on the pathogenesis and effective treatment of primary and secondary sarcopenia is limited. Traditional herbal active ingredients have biological activities that promote skeletal muscle health, showing potential preventive and therapeutic effects on sarcopenia. Therefore, this narrative review aims to provide a comprehensive overview of global traditional herbal active ingredients' beneficial therapeutic effects and molecular mechanisms on sarcopenia-related animal models. For this purpose, we conducted a literature search in three databases, PubMed, Web of Science, and Embase, consistent with the review objectives. After the screening, 12 animal studies met the review themes. The review results showed that the pathological mechanisms in sarcopenia-related animal models include imbalanced protein metabolism, oxidative stress, inflammation, apoptosis, insulin resistance, endoplasmic reticulum stress, impaired mitochondrial biogenesis, and autophagy-lysosome system aggravation. Eleven traditional herbal active ingredients exerted positive anti-sarcopenic effects by ameliorating these pathological mechanisms. This narrative review will provide meaningful insight into future studies regarding traditional herbal active ingredients for treating sarcopenia.
肌肉减少症是一个全球性的重大公共卫生问题，会损害个体的身体功能。2018年，欧洲老年肌肉减少症工作组2将肌肉减少症分为原发性和继发性肌肉减少症。然而，关于原发性和继发性肌肉减少症的发病机制及有效治疗方法的信息有限。传统草药活性成分具有促进骨骼肌健康的生物活性，对肌肉减少症显示出潜在的预防和治疗作用。因此，本叙述性综述旨在全面概述全球传统草药活性成分对肌肉减少症相关动物模型的有益治疗作用及分子机制。为此，我们在与综述目标一致的三个数据库（PubMed、Web of Science和Embase）中进行了文献检索。筛选后，有12项动物研究符合综述主题。综述结果表明，肌肉减少症相关动物模型中的病理机制包括蛋白质代谢失衡、氧化应激、炎症、细胞凋亡、胰岛素抵抗、内质网应激、线粒体生物合成受损以及自噬-溶酶体系统加重。11种传统草药活性成分通过改善这些病理机制发挥了积极的抗肌肉减少症作用。本叙述性综述将为未来关于传统草药活性成分治疗肌肉减少症的研究提供有意义的见解。
