Ma Kai, Huang Fengxiang, Qiao Ruiping, Miao Lijun
Department of Respiratory Disease, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Front Physiol. 2022 Jul 19;13:850964. doi: 10.3389/fphys.2022.850964. eCollection 2022.
Chronic obstructive pulmonary disease (COPD) is a common pulmonary disease characterized by persistent respiratory symptoms and airflow obstruction. In addition to lung diseases, chronic obstructive pulmonary disease (COPD) is often associated with other organ diseases, and sarcopenia is one of the common diseases. In recent years, multiple factors have been proposed to influence muscle dysfunction in COPD patients, including systemic and local inflammation, oxidative stress, hypoxia, hypercapnia, protein synthesis, catabolic imbalance, nutritional changes, disuse, ageing, and the use of medications such as steroids. These factors alone or in combination can lead to a reduction in muscle mass and cross-sectional area, deterioration of muscle bioenergy metabolism, defects in muscle repair and regeneration mechanisms, apoptosis and other anatomical and/or functional pathological changes, resulting in a decrease in the muscle's ability to work. This article reviews the research progress of possible pathogenesis of sarcopenia in COPD.
慢性阻塞性肺疾病（COPD）是一种常见的肺部疾病，其特征为持续的呼吸道症状和气流受限。除肺部疾病外，慢性阻塞性肺疾病（COPD）常与其他器官疾病相关，肌肉减少症就是其中一种常见疾病。近年来，已提出多种因素会影响COPD患者的肌肉功能障碍，包括全身和局部炎症、氧化应激、缺氧、高碳酸血症、蛋白质合成、分解代谢失衡、营养变化、废用、衰老以及使用类固醇等药物。这些因素单独或共同作用可导致肌肉质量和横截面积减少、肌肉生物能量代谢恶化、肌肉修复和再生机制缺陷、细胞凋亡以及其他解剖学和/或功能性病理变化，从而导致肌肉工作能力下降。本文综述了COPD中肌肉减少症可能发病机制的研究进展。
