Jiang Zhiyong, Ma Xiangjun, Song Kaixuan, Wang Tianzhu, Dong Mengxi, Liu Hang, Gao Hu, Wang Xiaoqing, Zhao Jing, Liu Zhipeng
College of Materials Science and Engineering, College of Science, Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University Nanjing 210037 China
Chemistry and Biomedicine Innovation Center (ChemBIC), State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University Nanjing 210023 China
Chem Sci. 2025 Aug 27. doi: 10.1039/d5sc03864b.
J-Aggregates hold significant promise for high-resolution shortwave infrared (SWIR) imaging, yet achieving robust SWIR absorption and emission simultaneously has been hindered by hypsochromic shifts in absorption and emission quenching caused by undesirable H- and random aggregation. To address this, we developed highly fluorescent BODIPY J-aggregates exhibiting absorption and emission spanning 1000-1600 nm. A key innovation was the implementation of a zig-zag molecular design, which effectively suppressed H-aggregation and minimized intermolecular interactions, thereby enabling anti-quenching SWIR emission. This design strategy was successfully translated into practical applications, yielding water-soluble nanoparticles capable of micron-resolution, multiplexed fluorescence, and photoacoustic imaging. This work establishes crucial design principles for creating highly efficient SWIR imaging agents.
J聚集体在高分辨率短波红外（SWIR）成像方面具有巨大潜力，但由于不良的H聚集和随机聚集导致吸收光谱蓝移和发射猝灭，同时实现强大的SWIR吸收和发射一直受到阻碍。为了解决这个问题，我们开发了具有高荧光性的BODIPY J聚集体，其吸收和发射范围为1000 - 1600 nm。一项关键创新是采用了锯齿形分子设计，该设计有效抑制了H聚集并最小化了分子间相互作用，从而实现了抗猝灭的SWIR发射。这种设计策略成功转化为实际应用，得到了能够进行微米级分辨率、多重荧光和光声成像的水溶性纳米颗粒。这项工作为创建高效的SWIR成像剂确立了关键的设计原则。
