胃癌免疫相关预后标志物的鉴定。
Identification of Immune-Related Prognostic Markers in Gastric Cancer.
机构信息
Department of Gastroenterology, Provincial Hospital Affiliated to Shandong University, Jinan 266042, Shandong, China.
Department of Gastroenterology, The Affiliated Qingdao Central Hospital of Qingdao University, Qingdao 266000, Shandong, China.
出版信息
J Healthc Eng. 2022 Mar 8;2022:7897274. doi: 10.1155/2022/7897274. eCollection 2022.
Gastric cancer (GC) is a malignant tumor with a high fatality rate. Poor prognosis is the main cause of death caused by GC. In this study, the gene expression difference between GC and the control group was analyzed. Differentially expressed genes (DEGs) related to immunity were screened for enrichment analysis. The differences in immune cell infiltration and immune function between GC and normal were identified. Cox regression analysis and survival analysis were used to determine the prognostic genes of GC in TCGA and GSE62254. The potential prognostic role of genes was further evaluated by risk score. Difference genes in GC were analyzed in TCGA. Candidate genes in TCGA and GSE62254 are analyzed, and prognostic genes are determined. The potential prognostic role of genes was further evaluated by risk score. The immune-related prognostic markers in GC were determined. FABP4, LBP, LCN1, CMA1, INHBA, ANGPTL1, ACKR1, GHR, and OGN may be used as markers for monitoring the prognosis of GC in the future.
胃癌（GC）是一种死亡率较高的恶性肿瘤。预后不良是导致 GC 死亡的主要原因。本研究分析了 GC 与对照组之间的基因表达差异，筛选与免疫相关的差异表达基因（DEGs）进行富集分析，鉴定 GC 与正常组织之间免疫细胞浸润和免疫功能的差异，采用 Cox 回归分析和生存分析确定 TCGA 和 GSE62254 中 GC 的预后基因，通过风险评分进一步评估基因的潜在预后作用。在 TCGA 中分析 GC 的差异基因，分析 TCGA 和 GSE62254 中的候选基因，并确定预后基因。通过风险评分进一步评估基因的潜在预后作用。确定 GC 中的免疫相关预后标志物。FABP4、LBP、LCN1、CMA1、INHBA、ANGPTL1、ACKR1、GHR 和 OGN 可能成为未来监测 GC 预后的标志物。
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