紫杉醇治疗患者的黄斑裂孔手术后视网膜光毒性
Retinal phototoxicity after macular hole surgery in a patient under paclitaxel.
机构信息
Puerta de Hierro-Majadahonda University Hospital, C/ Manuel de Falla, 1, Majadahonda (Madrid), 28222, Spain.
Department of Ophthalmology, Castilla La Mancha University, Albacete, Spain.
出版信息
BMC Ophthalmol. 2023 Aug 1;23(1):342. doi: 10.1186/s12886-023-03086-x.
BACKGROUND
The purpose is to report the second case, to our knowledge, of suspected paclitaxel-induced phototoxic maculopathy following pars plana vitrectomy surgery.
CASE PRESENTATION
63-year-old phakic female who underwent an uneventful phaco-vitrectomy to treat a complete macular hole, developing macular phototoxicity in the post-operatively period that could not be explained by the surgery itself and could only be attributed to a possible photosensitization induced by the previous use of paclitaxel.
CONCLUSIONS
The use of paclitaxel has been widely extended as a chemotherapy drug to treat breast cancer. It works by altering the intracellular microtubular reorganization and, based on this mechanism of action, photosensitivity has been previously described. We report a case of suspected paclitaxel-induced macular phototoxicity following ocular endoillumination during vitrectomy surgery.
背景
目的是报告第二例，据我们所知，在接受经睫状体平坦部玻璃体切除术（ pars plana vitrectomy surgery）后，疑似紫杉醇诱导的光毒性黄斑病变。
病例介绍
63 岁女性，无晶状体，接受了无晶状体超声乳化联合玻璃体切除术，以治疗完全性黄斑裂孔。术后出现黄斑光毒性，不能用手术本身来解释，只能归因于之前使用紫杉醇可能引起的光敏性。
结论
紫杉醇已被广泛用作治疗乳腺癌的化疗药物。它通过改变细胞内微管的重组而起作用，基于这种作用机制，先前已经描述了光敏性。我们报告了一例在玻璃体切除术中眼内照明后疑似紫杉醇诱导的黄斑光毒性的病例。
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