Fan Tianlun, Li Xiating, Zhang Xiang, Zhang Jing, Sun Lichun, Chen Jingjing, Fu Chuan
Department of Rehabilitation Medicine, the First Affiliated Hospital of Hainan Medical College, Hainan, China.
Department of Neurology, the First Affiliated Hospital of Hainan Medical College, Hainan, China.
Turk J Biol. 2022 Apr 25;46(4):288-297. doi: 10.55730/1300-0152.2617. eCollection 2022.
Accumulating evidence shows that gut microbial dysbiosis may represent a risk factor for Parkinson's disease (PD). Exercise has a positive effect on microbiota in general. The effect of aerobic exercise training (AET) on the gut microbial environment in PD remains to be explored. Here, we performed the 16S rRNA gene sequencing on feces from sham operated-mice (sham), PD mice model, and mice receiving AET (AET). Results indicated that AET had no remarkable effect on species richness and bacterial diversity of PD mice. The relative abundance of the was reduced, while , , , , , , , , , and were increased in PD mice compared with those of sham operated-mice, whereas AET partly rescued their abundance. Additionally, the composition proportion of beneficial and u significantly increased in AET mice compared to PD mice. Moreover, discriminative bacteria, such as , , , , and were identified as a specific taxon in AET mice. Here we provide evidence that AET can improve the gut microbiota of PD mice.
越来越多的证据表明，肠道微生物失调可能是帕金森病（PD）的一个风险因素。一般来说，运动对微生物群有积极影响。有氧运动训练（AET）对PD患者肠道微生物环境的影响仍有待探索。在此，我们对假手术小鼠（假手术组）、PD小鼠模型和接受AET的小鼠（AET组）的粪便进行了16S rRNA基因测序。结果表明，AET对PD小鼠的物种丰富度和细菌多样性没有显著影响。与假手术小鼠相比，PD小鼠中 的相对丰度降低，而 、 、 、 、 、 、 、 、 和 的相对丰度增加，而AET部分恢复了它们的丰度。此外，与PD小鼠相比，AET小鼠中有益的 和 的组成比例显著增加。此外，在AET小鼠中， 、 、 、 和 等鉴别细菌被确定为特定分类群。在此，我们提供证据表明AET可以改善PD小鼠的肠道微生物群。
