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定殖于小鼠胃上皮的乳酸杆菌菌株中的脂磷壁酸。

Lipoteichoic acids in Lactobacillus strains that colonize the mouse gastric epithelium.

作者信息

Sherman L A, Savage D C

出版信息

Appl Environ Microbiol. 1986 Aug;52(2):302-4. doi: 10.1128/aem.52.2.302-304.1986.

Abstract

Extracts of cells of 22 strains of Lactobacillus species, and of fluids from cultures in a defined medium of two of the strains, were assayed by hemagglutination inhibition for lipoteichoic acids. A total of 10 of the preparations gave positive tests for the acids, including those from eight strains known to adhere to the keratinized squamous epithelium of the mouse stomach. These findings are consistent with an hypothesis that lactobacilli colonize the epithelial surface via adhesive interaction with the keratinized cells mediated by macromolecular complexes containing lipoteichoic acids.

摘要

对22种乳酸杆菌属菌株的细胞提取物以及其中两种菌株在特定培养基中培养的培养液进行了脂磷壁酸的血凝抑制测定。总共有10种制剂对该酸呈阳性反应,包括来自已知能黏附于小鼠胃角质化鳞状上皮的8种菌株的制剂。这些发现与一种假说相符,即乳酸菌通过含有脂磷壁酸的大分子复合物介导的与角质化细胞的黏附相互作用在上皮表面定殖。

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