Sackeyfio A C, Lugeleka O M
Arch Int Pharmacodyn Ther. 1986 May;281(1):169-76.
An investigation has been carried out to determine whether the aqueous extract of Ficus elastica is active as an anti-inflammatory agent in the carrageenin-induced oedema and adjuvant-induced arthritis in the rat. This investigation was prompted by the fact that practitioners of herbal medicine in West Africa use the plant for the treatment of muscle and joint pain. The results of the investigation clearly indicated that orally administered Ficus elastica extract markedly inhibited the experimentally induced inflammation in the two test models. This effect of Ficus elastica was very similar to that of indomethacin. Thus in the carrageenin-induced oedema Ficus elastica (2-10 mg/kg) and indomethacin (1-5 mg/kg) produced inhibition of the magnitude of 5.41-68.92% and 27.03-69.26%, respectively. Similarly, both the extract of Ficus elastica and indomethacin inhibited the primary as well as the secondary lesions of adjuvant arthritis in the rat. The extract used in this study was coloured buff and there is considerable evidence that flavonoids of plant origin possess anti-inflammatory activity. Therefore it may be concluded that the anti-inflammatory activity of the extract of Ficus elastica was probably due to the presence of a pigment of the flavonoid class. Further studies are in progress to elucidate the chemical characteristics of this active principle.
已经开展了一项研究，以确定印度榕的水提取物在角叉菜胶诱导的大鼠水肿和佐剂诱导的大鼠关节炎中是否具有抗炎活性。西非的草药从业者使用这种植物治疗肌肉和关节疼痛，这一事实促使了这项研究。研究结果清楚地表明，口服印度榕提取物能显著抑制两种试验模型中实验诱导的炎症。印度榕的这种作用与消炎痛非常相似。因此，在角叉菜胶诱导的水肿中，印度榕（2 - 10毫克/千克）和消炎痛（1 - 5毫克/千克）的抑制率分别为5.41 - 68.92%和27.03 - 69.26%。同样，印度榕提取物和消炎痛都能抑制大鼠佐剂性关节炎的原发性和继发性病变。本研究中使用的提取物呈浅黄色，有大量证据表明植物来源的黄酮类化合物具有抗炎活性。因此，可以得出结论，印度榕提取物的抗炎活性可能归因于黄酮类色素的存在。进一步的研究正在进行中，以阐明这种活性成分的化学特性。
