Zhang Xiangli, Ma Yuanya, Chen Ziyan, Jiang Hong, Fan Zengjie
Key Laboratory of Dental Maxillofacial Reconstruction and Biological Intelligence Manufacturing, School of Stomatology, Lanzhou University, Gansu Province, Lanzhou, 730000, P. R. China.
Adv Healthc Mater. 2023 Dec;12(31):e2301729. doi: 10.1002/adhm.202301729. Epub 2023 Aug 3.
Peripheral nerve defects, particularly those of a larger size, pose a significant challenge in clinical practice due to their limited regenerative capacity. To tackle this challenge, an advanced self-powered enzyme-linked microneedle (MN) nerve conduit is designed and fabricated. This innovative conduit is composed of anodic and cathodic MN arrays, which contain glucose oxidase (GOx) and horseradish peroxidase (HRP) encapsulated in ZIF-8 nanoparticles, respectively. Through an enzymatic cascade reaction, this MN nerve conduit generates microcurrents that stimulate the regeneration of muscles, blood vessels, and nerve fibers innervated by the sciatic nerve, eventually accelerating the repair of sciatic nerve injury. It is clear that this self-powered MN nerve conduit will revolutionize traditional treatment methods for sciatic nerve injury and find widespread application in the field of nerve tissue repair.
周围神经缺损，尤其是较大尺寸的缺损，由于其有限的再生能力，在临床实践中构成了重大挑战。为应对这一挑战，设计并制造了一种先进的自供电酶联微针（MN）神经导管。这种创新的导管由阳极和阴极MN阵列组成，分别包含封装在ZIF-8纳米颗粒中的葡萄糖氧化酶（GOx）和辣根过氧化物酶（HRP）。通过酶级联反应，这种MN神经导管产生微电流，刺激由坐骨神经支配的肌肉、血管和神经纤维的再生，最终加速坐骨神经损伤的修复。显然，这种自供电的MN神经导管将彻底改变坐骨神经损伤的传统治疗方法，并在神经组织修复领域得到广泛应用。
