Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Center of Fetal Medicine, Department of Obstetrics, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Acta Obstet Gynecol Scand. 2023 Nov;102(11):1531-1540. doi: 10.1111/aogs.14632. Epub 2023 Aug 2.
The aim of this cross-sectional questionnaire study was to investigate motivation to participate in a possible new screening for preeclampsia in the first trimester of pregnancy among Danish pregnant women through a questionnaire based on Theory of Planned Behavior developed for this specific purpose. The new screening combines maternal characteristics with mean arterial pressure, uterine artery pulsatility index and biochemical markers to predict the risk of preeclampsia, whereas the current Danish screening uses maternal characteristics alone.
Participation was offered to a proportion of women attending a first or a second trimester screening scan at two University Hospitals in Copenhagen. The questionnaire was set up in REDCap® and answers were entered directly into the database, which was accessed via a QR-code.
We invited 772 pregnant women to participate in the questionnaire survey between November 2021 and April 2022 at Copenhagen University Hospital Rigshospitalet (study site one) (n = 238) and Copenhagen University Hospital Hvidovre (study site two) (n = 534). The response rate was 71.8% (171/238) at study site one and 33.9% (181/534) at study site two. A total of 352 women were included in the study (total participation rate 45.6%). Most women had a positive attitude towards preeclampsia screening in pregnancy, and 99.4% said they would participate in a risk assessment for preeclampsia if given the opportunity. A total of 97.4% answered "yes" to whether a first trimester preeclampsia screening should be offered to all pregnant women in Denmark. Positive motivation to participate in preeclampsia screening was correlated with having a network with a positive attitude towards preeclampsia screening.
The results of this study indicate that Danish pregnant women have a positive attitude towards participation in a first trimester screening for preeclampsia. This observation might be useful in relation to possible future implementation in Denmark.
本横断面问卷调查研究的目的是通过专门为此目的开发的基于计划行为理论的问卷，调查丹麦孕妇对在妊娠早期进行新的子痫前期筛查的参与动机。新的筛查结合了母体特征、平均动脉压、子宫动脉搏动指数和生化标志物来预测子痫前期的风险，而目前丹麦的筛查仅使用母体特征。
在哥本哈根的两家大学医院，向参加第一次或第二次妊娠中期筛查扫描的部分孕妇提供了参与机会。问卷是在 REDCap®中设置的，答案直接输入数据库，通过 QR 码访问数据库。
我们于 2021 年 11 月至 2022 年 4 月在哥本哈根大学医院 Rigshospitalet（研究地点一）（n=238）和哥本哈根大学医院 Hvidovre（研究地点二）（n=534）邀请了 772 名孕妇参加问卷调查。研究地点一的回复率为 71.8%（171/238），研究地点二的回复率为 33.9%（181/534）。共有 352 名妇女被纳入研究（总参与率为 45.6%）。大多数孕妇对妊娠子痫前期筛查持积极态度，99.4%的孕妇表示如果有机会，他们将参与子痫前期风险评估。共有 97.4%的孕妇回答“是”，即丹麦是否应向所有孕妇提供妊娠早期子痫前期筛查。积极参与子痫前期筛查的动机与拥有对子痫前期筛查持积极态度的网络有关。
本研究结果表明，丹麦孕妇对参与妊娠早期子痫前期筛查持积极态度。这一观察结果可能对丹麦未来的实施有用。
