Chen Rifeng, Li Xiuying, Zheng Dongyan, Cao Cunwei, Su Jiaguang
Department of Dermatology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, People's Republic of China.
Infect Drug Resist. 2023 Jul 27;16:4913-4918. doi: 10.2147/IDR.S414763. eCollection 2023.
(TM) and (PJ) infection are opportunistic infections that typically affect individuals with compromised immune systems, such as those with HIV or immunodeficiency. However, these infections are rarely seen in patients with systemic lupus erythematosus (SLE). We present a case study of a 52-year-old woman diagnosed with SLE who developed a co-infection of TM and PJ after receiving glucocorticoids, mycophenolate mofetil (MMF), and belimumab therapy. The patient's pneumonia improved following treatment with voriconazole, clarithromycin, and compound sulfamethoxazole. This case highlights the potential risk of serious opportunistic infections in SLE patients receiving a combination of glucocorticoids, MMF, and belimumab. Close monitoring of lymphocyte count, immunoglobulin levels, and chest computed tomography scans can aid in the early detection of infections. To the best of our knowledge, this is the first reported case of TM and PJ co-infection in an SLE patient.
（卡氏肺孢子菌）（TM）和（耶氏肺孢子菌）（PJ）感染是机会性感染，通常影响免疫系统受损的个体，如艾滋病毒感染者或免疫缺陷者。然而，这些感染在系统性红斑狼疮（SLE）患者中很少见。我们报告一例52岁女性SLE患者的病例研究，该患者在接受糖皮质激素、霉酚酸酯（MMF）和贝利尤单抗治疗后发生了TM和PJ合并感染。患者的肺炎在接受伏立康唑、克拉霉素和复方磺胺甲恶唑治疗后有所改善。该病例突出了接受糖皮质激素、MMF和贝利尤单抗联合治疗的SLE患者发生严重机会性感染的潜在风险。密切监测淋巴细胞计数、免疫球蛋白水平和胸部计算机断层扫描有助于早期发现感染。据我们所知，这是首例报道的SLE患者TM和PJ合并感染病例。
