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酰胺类局部麻醉药对多种自由基直接清除活性的剂量-反应关系。

The dose-response relationships of the direct scavenging activity of amide-based local anesthetics against multiple free radicals.

作者信息

Sato Yukiko, Matsumoto Shigekiyo, Ogata Kazue, Bacal Kira, Nakatake Misato, Kitano Takaaki, Tokumaru Osamu

机构信息

Department of Fundamental Nursing, School of Nursing, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, Japan.

Department of Anesthesiology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, Japan.

出版信息

J Clin Biochem Nutr. 2023 Jul;73(1):16-23. doi: 10.3164/jcbn.22-131. Epub 2023 May 9.

DOI:10.3164/jcbn.22-131
PMID:37534092
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10390804/
Abstract

This study aimed to illustrate the dose-response relationships of the direct scavenging activity of amide-based local anesthetics against multiple free radicals . We have demonstrated that amide-type local anesthetics selectively and directly scavenge some free radicals. Three kinds of free radicals were eliminated by all the four local anesthetics examined. Mepivacaine, lidocaine, bupivacaine, and dibucaine scavenged hydroxyl radicals in dose-dependent manners. Ascorbyl free radicals were also scavenged in dose-dependent manners, and lastly singlet oxygen was scavenged in dose-dependent manners. Three other free radicals were not scavenged by all of the four local anesthetics; -butoxyl radical was scavenged by all the anesthetics examined but dibucaine, nitric oxide by mepivacaine but not by the other three, and tyrosyl radical by mepivacaine and lidocaine but not by the other two. Some free radicals (superoxide anion, -butyl peroxyl radical, DPPH) were not scavenged by any of the four local anesthetics. The local anesthetics were also shown to inhibit lipid peroxidation by TBARS assay. These results suggest that local anesthetics have antioxidant properties through their free radical scavenging activities.

摘要

本研究旨在阐明酰胺类局部麻醉药对多种自由基的直接清除活性的剂量反应关系。我们已经证明酰胺型局部麻醉药能选择性地直接清除一些自由基。所检测的四种局部麻醉药均可清除三种自由基。甲哌卡因、利多卡因、布比卡因和丁卡因均以剂量依赖方式清除羟自由基。抗坏血酸自由基也以剂量依赖方式被清除，最后单线态氧也以剂量依赖方式被清除。另外三种自由基不能被所有四种局部麻醉药清除；丁氧自由基能被除丁卡因外的所有检测麻醉药清除，一氧化氮能被甲哌卡因清除而不能被其他三种清除，酪氨酰自由基能被甲哌卡因和利多卡因清除而不能被其他两种清除。某些自由基（超氧阴离子、丁基过氧自由基、二苯代苦味酰自由基）不能被任何一种局部麻醉药清除。通过硫代巴比妥酸反应物（TBARS）测定还表明局部麻醉药能抑制脂质过氧化。这些结果表明局部麻醉药通过其自由基清除活性具有抗氧化特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12f2/10390804/51e698d490d3/jcbn22-131f05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12f2/10390804/48de637898bc/jcbn22-131f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12f2/10390804/b784411f9e21/jcbn22-131f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12f2/10390804/0d822ba7e670/jcbn22-131f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12f2/10390804/b31319965dac/jcbn22-131f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12f2/10390804/51e698d490d3/jcbn22-131f05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12f2/10390804/48de637898bc/jcbn22-131f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12f2/10390804/b784411f9e21/jcbn22-131f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12f2/10390804/0d822ba7e670/jcbn22-131f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12f2/10390804/b31319965dac/jcbn22-131f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12f2/10390804/51e698d490d3/jcbn22-131f05.jpg

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