World-Class Research Center, Digital Biodesign and Personalized Healthcare, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991, Moscow, Russia.
Cardiovasc Hematol Agents Med Chem. 2024;22(2):114-120. doi: 10.2174/1871525721666230803102554.
Hypothermia and autophagy are critical regulators of cell homeostasis by regulating intra and intercellular cell communication. Myocardiocyte cryotherapy poses multiple cellular and subcellular effects on the injured cell, including upregulation of autophagy. Autophagy plays a crucial role in modifying cell metabolism by regulating downregulation, reducing reactive oxygen species production, and improving the natural cellular antioxidant defense system. Reduction of reactive oxygen species production and improving natural cellular antioxidant defense system. Therapeutic hypothermia ranges from 32-34°C in terms of local myocardiocyte cooling. Hypothermia induces autophagy by phosphorylating the Akt signaling pathway. Hypothermia has a more therapeutic effect when applied at the beginning of reperfusion rather than in the beginning of ischemia. Moderate hypothermia with 33°C poses most therapeutic effect by viability maintaining and reduction of reactive oxygen species release. Application of local hypothermia to myocardiocytes can be applied to infarcted myocardiocytes, anginal and to the cardiomyopathies.
低温和自噬通过调节细胞内和细胞间通讯，是细胞内稳态的关键调节因子。心肌细胞冷冻疗法对受损细胞具有多种细胞和亚细胞作用，包括自噬的上调。自噬通过调节细胞代谢的下调、减少活性氧的产生和改善天然细胞抗氧化防御系统来发挥关键作用。减少活性氧的产生和改善天然细胞抗氧化防御系统。局部心肌细胞冷却的治疗性低温范围在 32-34°C。低温通过磷酸化 Akt 信号通路诱导自噬。低温在再灌注开始时应用比在缺血开始时具有更好的治疗效果。33°C 的适度低温通过维持活力和减少活性氧释放来发挥最大的治疗效果。将局部低温应用于心肌细胞可以应用于梗死的心肌细胞、心绞痛和心肌病。
