Department of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, Missouri, USA.
Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.
Alzheimers Dement. 2023 Oct;19(10):4454-4462. doi: 10.1002/alz.13400. Epub 2023 Aug 3.
Neuronal health as a potential underlying mechanism of the beneficial effects of exercise has been understudied in humans. Furthermore, there has been limited consideration of potential moderators (e.g., cardiovascular health) on the effects of exercise.
Clinically normal middle-aged and older adults completed a validated questionnaire about exercise engagement over a 10-year period (n = 75; age 63 ± 8 years). A composite estimate of neuronal injury was formulated that included cerebrospinal fluid-based measures of visinin-like protein-1, neurogranin, synaptosomal-associated protein 25, and neurofilament light chain. Cardiovascular risk was estimated using the Framingham Risk Score.
Cross-sectional analyses showed that greater exercise engagement was associated with less neuronal injury in the group with lower cardiovascular risk (p = 0.008), but not the group with higher cardiovascular risk (p = 0.209).
Cardiovascular risk is an important moderator to consider when examining the effects of exercise on cognitive and neural health, and may be relevant to personalized exercise recommendations.
We examined the association between exercise engagement and neuronal injury. Vascular risk moderated the association between exercise and neuronal injury. Cardiovascular risk may be relevant to personalized exercise recommendations.
作为运动有益影响的潜在潜在机制，神经元健康在人类中研究不足。此外，对于运动效果的潜在调节因素（例如心血管健康）的考虑也很有限。
临床正常的中年和老年人在 10 年内完成了关于运动参与情况的经过验证的问卷（n=75；年龄 63±8 岁）。制定了一个包含神经丝轻链在内的神经元损伤综合估计，该估计包括脑脊液中视蛋白样蛋白-1、神经颗粒蛋白、突触相关蛋白 25 的测量值。心血管风险使用弗雷明汉风险评分进行评估。
横断面分析显示，在心血管风险较低的组中，更多的运动参与与较少的神经元损伤相关（p=0.008），而在心血管风险较高的组中则没有相关性（p=0.209）。
在检查运动对认知和神经健康的影响时，心血管风险是一个需要考虑的重要调节因素，并且可能与个性化的运动建议有关。
我们检查了运动参与度与神经元损伤之间的关联。血管风险调节了运动与神经元损伤之间的关联。心血管风险可能与个性化的运动建议有关。
