肝癌研究用猪模型的当前进展。

Current progress of pig models for liver cancer research.

机构信息

Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, First Hospital of Jilin University, Changchun, China; National-Local Joint Engineering Laboratory of Animal Models for Human Disease, First Hospital of Jilin University, Changchun, China.

Invasive Technology Nursing Platform, First Hospital of Jilin University, Changchun, China.

出版信息

Biomed Pharmacother. 2023 Sep;165:115256. doi: 10.1016/j.biopha.2023.115256. Epub 2023 Aug 1.

DOI:10.1016/j.biopha.2023.115256

PMID:37536038

Abstract

Preclinical trials play critical roles in assessing the safety and efficiency of novel therapeutic strategies for human diseases including live cancer. However, most therapeutic strategies that were proved to be effective in preclinical cancer models failed in human clinical trials due to the lack of appropriate disease animal models. Therefore, it is of importance and urgent to develop a precise animal model for preclinical cancer research. Liver cancer is one of the most frequently diagnosed cancers with low 5-year survival rate. Recently, porcine attracted increasing attentions as animal model in biomedical research. Porcine liver cancer model may provide a promising platform for biomedical research due to their similarities to human being in body size, anatomical characteristics, physiology and pathophysiology. In this review, we comprehensively summarized and discussed the advantages and disadvantages, rationale, current status and progress of pig models for liver cancer research.

摘要

临床前试验在评估包括癌症在内的人类疾病的新型治疗策略的安全性和有效性方面发挥着关键作用。然而，由于缺乏合适的疾病动物模型，大多数在临床前癌症模型中被证明有效的治疗策略在人体临床试验中失败。因此，开发用于临床前癌症研究的精确动物模型非常重要和紧迫。肝癌是最常见的癌症之一，5 年生存率低。最近，猪作为生物医学研究中的动物模型引起了越来越多的关注。由于猪在体型、解剖特征、生理和病理生理学方面与人类相似，猪肝癌模型可能为生物医学研究提供一个有前途的平台。在这篇综述中，我们全面总结和讨论了猪肝癌模型用于肝癌研究的优缺点、原理、现状和进展。