Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, 221 Longwood Avenue BL-341, Boston, MA 02115, USA.
Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, 221 Longwood Avenue BL-341, Boston, MA 02115, USA; Harvard Medical School, Boston, MA, USA.
Clin Perinatol. 2023 Sep;50(3):625-641. doi: 10.1016/j.clp.2023.04.001. Epub 2023 May 15.
Human milk is the preferred diet for very preterm infants due to short-term and long-term benefits for health and neurodevelopment. Fortification of human milk is required to deliver sufficient nutrients to attain recommended growth targets during the neonatal hospitalization. Intrinsic variability in human milk composition poses a challenge in clinical practice because some infants fail to meet recommended nutrient intakes even with existing approaches of standard (fixed-dose) and adjustable fortification. Individually targeted fortification is an emerging strategy to minimize nutrition delivery gaps through application of point-of-care human milk analysis and has potential to improve growth and related outcomes.
母乳是极早产儿的首选喂养方式，因为它对短期和长期的健康和神经发育都有益处。为了在新生儿住院期间提供足够的营养以达到推荐的生长目标，需要对母乳进行强化。母乳成分的固有可变性给临床实践带来了挑战，因为即使采用现有的标准（固定剂量）和可调节强化方法，仍有一些婴儿无法达到推荐的营养素摄入量。个体化靶向强化是一种通过应用即时人乳分析来最小化营养输送差距的新兴策略，有可能改善生长和相关结果。
