一款用于IBM个人计算机的计算机程序，可在长目标DNA序列中搜索与短寡核苷酸序列的近似匹配项。

Computer program for the IBM personal computer which searches for approximate matches to short oligonucleotide sequences in long target DNA sequences.

作者信息

Myers E W, Mount D W

出版信息

Nucleic Acids Res. 1986 Jan 10;14(1):501-8. doi: 10.1093/nar/14.1.501.

DOI:10.1093/nar/14.1.501

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC339434/

Abstract

We describe a program which may be used to find approximate matches to a short predefined DNA sequence in a larger target DNA sequence. The program predicts the usefulness of specific DNA probes and sequencing primers and finds nearly identical sequences that might represent the same regulatory signal. The program is written in the C programming language and will run on virtually any computer system with a C compiler, such as the IBM/PC and other computers running under the MS/DOS and UNIX operating systems. The program has been integrated into an existing software package for the IBM personal computer (see article by Mount and Conrad, this volume). Some examples of its use are given.

摘要

我们描述了一个程序，该程序可用于在较大的目标DNA序列中找到与短的预定义DNA序列的近似匹配。该程序可预测特定DNA探针和测序引物的效用，并找到可能代表相同调控信号的几乎相同的序列。该程序用C编程语言编写，几乎可以在任何带有C编译器的计算机系统上运行，如IBM/PC以及在MS/DOS和UNIX操作系统下运行的其他计算机。该程序已被集成到适用于IBM个人计算机的现有软件包中（见Mount和Conrad在本卷中的文章）。文中给出了一些使用该程序的示例。

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本文引用的文献

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Identification of common molecular subsequences.常见分子子序列的鉴定

J Mol Biol. 1981 Mar 25;147(1):195-7. doi: 10.1016/0022-2836(81)90087-5.

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Microcomputer programs for DNA sequence analysis.用于DNA序列分析的微机程序。

Nucleic Acids Res. 1982 Jan 11;10(1):31-8. doi: 10.1093/nar/10.1.31.

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Analysis of biological sequences on small computers.小型计算机上生物序列的分析

DNA. 1984 Dec;3(6):421-36. doi: 10.1089/dna.1.1984.3.421.

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Creating new restriction sites by silent changes in coding sequences.通过编码序列中的沉默变化创建新的限制酶切位点。

Gene. 1984 Dec;32(1-2):67-73. doi: 10.1016/0378-1119(84)90033-7.

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A general method applicable to the search for similarities in the amino acid sequence of two proteins.一种适用于寻找两种蛋白质氨基酸序列相似性的通用方法。

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