微生物产物。VIII. 氮杂丝氨酸菌素，一种新型的六环缩肽抗生素。

Microbial products. VIII. Azinothricin, a novel hexadepsipeptide antibiotic.

作者信息

Maehr H, Liu C M, Palleroni N J, Smallheer J, Todaro L, Williams T H, Blount J F

出版信息

J Antibiot (Tokyo). 1986 Jan;39(1):17-25. doi: 10.7164/antibiotics.39.17.

DOI:10.7164/antibiotics.39.17

Abstract

Azinothricin was isolated from the culture filtrate of Streptomyces sp. X-14950 in crystalline form. It represents a new type of hexadepsipeptide antibiotic as it contains a 19-membered cyclodepsipeptide ring composed of six unusual amino acids and bearing a novel C21 side chain. Azinothricin was identified as [(3S,4S,7R(S*),10S,17R,20S,23R)[2S(2'R*,5'S*, 6'S*)3S*]]-alpha-ethyl-6-(3-ethyl-1, 5-dimethyl-4-oxo-1,5-heptadienyl)- N-(1,8, 14,15,18,21,27-heptaaza-21-hydroxy-7-(1-hydroxyethyl)-2,6,9,16,19, 22-hexaoxo-4-isopropyl-20-(methoxy-methyl)-17,18-dimethyl-5-oxa tricyclo [21.4.0.0(10,15)]heptacosan-3-yl)tetrahydro-alpha, 2-dihydroxy-5-methyl-2H-pyran-2-acetamide and is primarily active against Gram-positive microorganisms.

摘要

氮杂诺菌素是以结晶形式从链霉菌属X-14950的培养滤液中分离得到的。它代表了一种新型的六聚缩肽抗生素，因为它含有一个由六个不同寻常的氨基酸组成的19元环缩肽环，并带有一个新颖的C21侧链。氮杂诺菌素被鉴定为[(3S,4S,7R(S*),10S,17R,20S,23R)[2S(2'R*,5'S*, 6'S*)3S*]]-α-乙基-6-(3-乙基-1, 5-二甲基-4-氧代-1,5-庚二烯基)- N-(1,8, 14,15,18,21,27-七氮杂-21-羟基-7-(1-羟乙基)-2,6,9,16,19, 22-六氧代-4-异丙基-20-(甲氧基甲基)-17,18-二甲基-5-氧杂三环[21.4.0.0(10,15)]庚二十七烷-3-基)四氢-α, 2-二羟基-5-甲基-2H-吡喃-2-乙酰胺，主要对革兰氏阳性微生物有活性。