挥发性有机化合物在炎症性肠病中的诊断效用：系统评价和荟萃分析。
The Diagnostic Utility of Volatile Organic Compounds in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.
机构信息
Warwick Medical School, University of Warwick, Coventry, UK.
Department of Gastroenterology, Epsom and St Helier University Hospitals NHS Trust, Carshalton, Surrey, UK.
出版信息
J Crohns Colitis. 2024 Feb 26;18(2):320-330. doi: 10.1093/ecco-jcc/jjad132.
BACKGROUND
Volatile organic compounds [VOCs] show promise as potential biomarkers of for ulcerative colitis and Crohn's disease, two chronic, idiopathic, gastrointestinal disorders with diagnostic and management challenges. Non-invasive biomarkers aid early diagnosis and management. In this study we review studies of diagnostic accuracy of VOCs in inflammatory bowel disease.
METHODS
A systematic search was carried out on the Pubmed and Scopus databases; with 16 studies reviewed and meta-analysis carried out on 10.
RESULTS
Meta-analysis of 696 inflammatory bowel disease [IBD] cases against 605 controls revealed a pooled sensitivity and specificity of 87% (95% confidence interval [CI], 0.79 - 0.92) and 83% [95% CI, 0.73 - 0.90], respectively. Area under the curve [AUC] was 0.92.
CONCLUSION
VOCs perform very well as non-invasive biomarkers of IBD, with much scope for future improvement and research.
背景
挥发性有机化合物（VOCs）有望成为溃疡性结肠炎和克罗恩病的潜在生物标志物，这两种疾病是慢性、特发性胃肠道疾病，具有诊断和治疗方面的挑战。非侵入性生物标志物有助于早期诊断和管理。在这项研究中，我们回顾了关于挥发性有机化合物在炎症性肠病中的诊断准确性的研究。
方法
在 Pubmed 和 Scopus 数据库上进行了系统搜索；对 16 项研究进行了综述，并对 10 项研究进行了荟萃分析。
结果
对 696 例炎症性肠病（IBD）病例与 605 例对照进行荟萃分析，结果显示总体敏感性和特异性分别为 87%（95%置信区间[CI]，0.79-0.92）和 83%[95%CI，0.73-0.90]。曲线下面积（AUC）为 0.92。
结论
VOCs 作为 IBD 的非侵入性生物标志物表现非常出色，具有很大的改进和研究空间。
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