Ivaskiene Tatjana, Kaspute Greta, Ramanavicius Arunas, Prentice Urte
State Research Institute Centre for Innovative Medicine, LT-08410 Vilnius, Lithuania.
Department of Nanotechnology, State Research Institute Center for Physical Sciences and Technology (FTMC), LT-10257 Vilnius, Lithuania.
Gels. 2025 Apr 4;11(4):269. doi: 10.3390/gels11040269.
Gastroenterology faces significant challenges due to the global burden of gastrointestinal (GI) diseases, driven by socio-economic disparities and their wide-ranging impact on health and healthcare systems. Advances in molecularly imprinted polymers (MIPs) offer promising opportunities for developing non-invasive, cost-effective diagnostic tools that enhance the accuracy and accessibility of GI disease detection. This research explores the potential of MIP-based sensors in revolutionizing gastrointestinal diagnostics and improving early detection and disease management. Biomarkers are vital in diagnosing, monitoring, and personalizing disease treatment, particularly in gastroenterology, where advancements like MIPs offer highly selective and non-invasive diagnostic solutions. MIPs mimic natural recognition mechanisms, providing stability and sensitivity even in complex biological environments, making them ideal for early disease detection and real-time monitoring. Their integration with advanced technologies, including conducting polymers, enhances their functionality, enabling rapid, point-of-care diagnostics for gastrointestinal disorders. Despite regulatory approval and scalability challenges, ongoing innovations promise to revolutionize diagnostics and improve patient outcomes through precise approaches.
由于社会经济差异及其对健康和医疗保健系统的广泛影响所驱动的全球胃肠道（GI）疾病负担，胃肠病学面临着重大挑战。分子印迹聚合物（MIPs）的进展为开发非侵入性、具有成本效益的诊断工具提供了有前景的机会，这些工具可提高GI疾病检测的准确性和可及性。本研究探讨了基于MIP的传感器在彻底改变胃肠诊断以及改善早期检测和疾病管理方面的潜力。生物标志物在疾病诊断、监测和个性化治疗中至关重要，特别是在胃肠病学领域，MIPs等进展提供了高度选择性和非侵入性的诊断解决方案。MIPs模仿天然识别机制，即使在复杂的生物环境中也能提供稳定性和敏感性，使其成为早期疾病检测和实时监测的理想选择。它们与包括导电聚合物在内的先进技术的整合增强了其功能，能够对胃肠道疾病进行快速的即时诊断。尽管存在监管批准和可扩展性挑战，但正在进行的创新有望通过精确方法彻底改变诊断并改善患者预后。
