Department of Sports Biosciences, School of Sports Science, Central University of Rajasthan, Ajmer, India.
Ir J Med Sci. 2024 Apr;193(2):999-1007. doi: 10.1007/s11845-023-03469-5. Epub 2023 Aug 4.
Micro-RNA (miRs) targeting kinases and phosphatases regulate the hyper-phosphorylation of tau protein, which is a characteristic feature of Chronic Traumatic Encephalopathy (CTE).
Identification of lead dysregulated miR expressed in CTE, and other similar tauopathies.
A search strategy was devised using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to mine into multiple indexing databases such as Web of Science, Google Scholar, and PubMed spanning from 2005 to June 2022. Seven articles were screened out of 34,221 publications based on inclusion criteria and were categorized into two groups i.e., (1) CTE and its risk factors and (2) Age-related neurodegenerative disorders.
Statistical analysis [RevMan 5.4.1] results showed that the overall risk ratio (RR) of the first group is significant (RR = 0.62, 95% CI = [0.38, 1.00], z = 1.95, p = 0.05) whereas, the second group favours the control population (RR = 1.64, 95% CI = [0.85, 3.16], z = 1.14, p = 0.14).
We observed that among all other dysregulated miRs, miR-181c-5p is significantly overexpressed in Alzhimers disease (AD) and CTE. Further, we found that miR-210-3p is also upregulated notably in all groups. In sum, we conclude that these miRs can be considered as potential target and biomarker in the diagnosis and treatment of various tauopathies.
靶向激酶和磷酸酶的 micro-RNA（miRs）调节 tau 蛋白的过度磷酸化，这是慢性创伤性脑病（CTE）的一个特征。
鉴定 CTE 和其他类似 tau 病中表达失调的先导 miR。
根据系统评价和荟萃分析的首选报告项目（PRISMA）指南制定搜索策略，挖掘多个索引数据库，如 Web of Science、Google Scholar 和 PubMed，涵盖 2005 年至 2022 年 6 月的文献。根据纳入标准，从 34221 篇文献中筛选出 7 篇文献，并将其分为两组，即（1）CTE 及其危险因素和（2）与年龄相关的神经退行性疾病。
统计分析[RevMan 5.4.1]结果表明，第一组的总体风险比（RR）具有显著意义（RR=0.62，95%CI=[0.38, 1.00]，z=1.95，p=0.05），而第二组则有利于对照组（RR=1.64，95%CI=[0.85, 3.16]，z=1.14，p=0.14）。
我们观察到，在所有其他失调的 miR 中，miR-181c-5p 在阿尔茨海默病（AD）和 CTE 中显著过表达。此外，我们发现 miR-210-3p 在所有组中也明显上调。总之，我们得出结论，这些 miR 可以被认为是各种 tau 病诊断和治疗的潜在靶点和生物标志物。
