Foster N L, Tamminga C A, O'Donohue T L, Tanimoto K, Bird E D, Chase T N
Neurosci Lett. 1986 Jan 2;63(1):71-5. doi: 10.1016/0304-3940(86)90015-7.
Choline acetyltransferase (ChAT) activity and neuropeptide Y (NPY) levels in post-mortem tissues from patients with histologically proven Alzheimer's disease were compared with age-matched neurologically normal control individuals. Despite the high NPY concentrations in human cerebral cortex, no significant abnormalities were found. However, ChAT activity was reduced throughout the cortex, without a relationship to areas of functional deficit, as previously identified using fluorodeoxyglucose. These results lend further support to the concept of Alzheimer's disease as a highly selective neurodegenerative disorder.
将经组织学证实的阿尔茨海默病患者尸检组织中的胆碱乙酰转移酶（ChAT）活性和神经肽Y（NPY）水平与年龄匹配的神经功能正常对照个体进行了比较。尽管人类大脑皮层中NPY浓度很高，但未发现明显异常。然而，整个皮层的ChAT活性均降低，且与先前使用氟脱氧葡萄糖确定的功能缺陷区域无关。这些结果进一步支持了阿尔茨海默病是一种高度选择性神经退行性疾病的概念。
