Department of Tissue Engineering, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Student Research Committee, Tabriz University of Medical Science, Tabriz, Iran.
Stem Cell Res Ther. 2023 Aug 4;14(1):194. doi: 10.1186/s13287-023-03426-0.
Many problems related to disorders and defects of bone tissue caused by aging, diseases, and injuries have been solved by the multidisciplinary research field of regenerative medicine and tissue engineering. Numerous sciences, especially nanotechnology, along with tissue engineering, have greatly contributed to the repair and regeneration of tissues. Various studies have shown that the presence of magnetic nanoparticles (MNPs) in the structure of composite scaffolds increases their healing effect on bone defects. In addition, the induction of osteogenic differentiation of mesenchymal stem cells (MSCs) in the presence of these nanoparticles has been investigated and confirmed by various studies. Therefore, in the present article, the types of MNPs, their special properties, and their application in the healing of damaged bone tissue have been reviewed. Also, the molecular effects of MNPs on cell behavior, especially in osteogenesis, have been discussed. Finally, the present article includes the potential applications of MNP-containing nanocomposite scaffolds in bone lesions and injuries. In summary, this review article highlights nanocomposite scaffolds containing MNPs as a solution for treating bone defects in tissue engineering and regenerative medicine.
许多与衰老、疾病和损伤引起的骨骼组织紊乱和缺陷相关的问题，已经通过再生医学和组织工程这一多学科研究领域得到了解决。许多科学，特别是纳米技术，与组织工程一起，极大地促进了组织的修复和再生。各种研究表明，在复合支架的结构中存在磁性纳米颗粒（MNPs）会增加其对骨缺损的愈合效果。此外，已有多项研究证实，这些纳米颗粒的存在会诱导间充质干细胞（MSCs）的成骨分化。因此，在本文中，综述了 MNPs 的类型、它们的特殊性质以及它们在受损骨组织修复中的应用。此外，还讨论了 MNPs 对细胞行为的分子影响，特别是在成骨方面。最后，本文还包括了含 MNPs 的纳米复合材料支架在骨病变和损伤中的潜在应用。总之，本文强调了含有 MNPs 的纳米复合材料支架作为组织工程和再生医学中治疗骨缺损的一种解决方案。
