Zhang Gejing, Zhen Chenxiao, Yang Jiancheng, Wang Jianping, Wang Shenghang, Fang Yanwen, Shang Peng
School of Life Sciences, Northwestern Polytechnical University Xi'an Shaanxi 710072 China.
Research & Development Institute of Northwestern Polytechnical University Shenzhen 518057 China
Nanoscale Adv. 2024 Feb 12;6(8):1957-1973. doi: 10.1039/d3na00851g. eCollection 2024 Apr 16.
With the development of biotechnology, biomaterials have been rapidly developed and shown great potential in bone regeneration therapy and bone tissue engineering. Nanoparticles have attracted the attention of researches and have applied in various fields especially in the biomedical field as the special physicochemical properties. Nanoparticles were found to regulate bone remodeling depending on their size, shape, composition, and charge. Therefore, in-depth research was necessary to provide the basic support to select the most suitable nanoparticles for bone relate diseases treatment. This article reviews the current development of nanoparticles in bone tissue engineering, focusing on drug delivery, gene delivery, and cell labeling. In addition, the research progress on the interaction of nanoparticles with bone cells, focusing on osteoblasts, osteoclasts, and bone marrow mesenchymal stem cells, and the underlying mechanism were also reviewed. Finally, the current challenges and future research directions are discussed. Thus, detailed study of nanoparticles may reveal new therapeutic strategies to improve the effectiveness of bone regeneration therapy or other bone diseases.
随着生物技术的发展，生物材料得到了迅速发展，并在骨再生治疗和骨组织工程中显示出巨大潜力。纳米粒子因其特殊的物理化学性质而吸引了研究人员的关注，并已应用于各个领域，尤其是生物医学领域。研究发现，纳米粒子可根据其大小、形状、组成和电荷来调节骨重塑。因此，有必要进行深入研究，为选择最适合治疗骨相关疾病的纳米粒子提供基础支持。本文综述了纳米粒子在骨组织工程中的当前发展情况，重点关注药物递送、基因递送和细胞标记。此外，还综述了纳米粒子与骨细胞相互作用的研究进展，重点关注成骨细胞、破骨细胞和骨髓间充质干细胞，以及潜在机制。最后，讨论了当前面临的挑战和未来的研究方向。因此，对纳米粒子的详细研究可能会揭示新的治疗策略，以提高骨再生治疗或其他骨疾病的疗效。
