Qiao Xiaohui, Liang Jing, Qiu Luping, Feng Wei, Cheng Guangwen, Chen Yu, Ding Hong
Department of Ultrasound, Huashan Hospital, Fudan University, Shanghai, 200040, PR China.
Materdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 200444, PR China.
Biomaterials. 2023 Oct;301:122252. doi: 10.1016/j.biomaterials.2023.122252. Epub 2023 Jul 30.
An all-in-one therapy for cooperatively fighting cancer, infection and boosting wound repair is exceedingly demanded for patients with advanced superficial cancers or after surgical intervention to avoid multiple drug abuse and resultant adverse effects. Here, the ultrasound-activated nanosonosensitizer PHMP that integrated peroxymonosulfate (PMS) into the Pd-catalyzed hydrogenated mesoporous titanium dioxide (PHM) was dexterously designed for combined therapy of cancer and infected wound based on oxygen/sulfate dual-radical nanotherapy. Firstly, the PHM with single crystal structure and abundant oxygen deficiencies exhibited excellent ultrasound-excited reactive oxygen species (ROS) production for enhanced sonodynamic therapy (SDT) under the support of Pd nanozyme-mediated O supply. Simultaneously, the physically targeted ultrasound irradiation effectively transformed PMS loaded in the hollow cavities into distinct sulfate radical (•SO) with longer half-life and stronger oxidation, which remarkably enhanced the therapeutic efficacy of PHM-mediated SDT for cancer and bacteria. In addition, by embedding PHMP into the hydrogel, the enrichment of PHMP in the focal site was guaranteed, and meanwhile a moist and ventilated environment was created to speed up wound repair. The study broadens the potential of •SO in the therapeutic fields and contributes a simple and appealing tactic for the comprehensive treatment of cancer, infection and wound repair.
对于晚期浅表癌症患者或手术干预后的患者而言，迫切需要一种用于协同对抗癌症、感染和促进伤口修复的一体化疗法，以避免多种药物滥用及其产生的不良反应。在此，基于氧/硫酸根双自由基纳米疗法，巧妙设计了一种将过一硫酸盐（PMS）整合到钯催化氢化介孔二氧化钛（PHM）中的超声激活纳米声敏剂PHMP，用于癌症和感染伤口的联合治疗。首先，具有单晶结构和大量氧缺陷的PHM在钯纳米酶介导的氧供应支持下，表现出优异的超声激发活性氧（ROS）生成能力，可增强声动力疗法（SDT）。同时，物理靶向超声照射有效地将负载在中空腔内的PMS转化为具有更长半衰期和更强氧化性的独特硫酸根自由基（•SO），显著增强了PHM介导的SDT对癌症和细菌的治疗效果。此外，通过将PHMP嵌入水凝胶中，保证了PHMP在病灶部位的富集，同时营造了一个湿润通风的环境以加速伤口修复。该研究拓宽了•SO在治疗领域的潜力，并为癌症、感染和伤口修复的综合治疗提供了一种简单且有吸引力的策略。
