Department of Ultrasound, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, P. R. China.
Shanghai Engineering Research Center of Organ Repair, Materdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 200444, P. R. China.
Adv Sci (Weinh). 2022 Jun;9(17):e2200974. doi: 10.1002/advs.202200974. Epub 2022 Apr 30.
Variant modalities are quested and merged into the tumor nanotherapy by leveraging the excitation from external or intratumoral incentives. However, the ubiquitous hypoxia and the insufficient content of hydrogen peroxide (H O ) in tumor microenvironments inevitably hinder the effective production of reactive oxygen species (ROS). To radically extricate from the shackles, peroxymonosulfate (PMS: HSO )-loaded hollow mesoporous copper sulfide (CuS) nanoparticles (NPs) are prepared as the distinct ROS donors for sulfate radical (•SO )-mediated and stimuli-responsive tumor nanotherapy in an oxygen-independent manner. In this therapeutic modality, the second near-infrared laser irradiation, together with the released copper ions as well as the heat produced by CuS after illumination, work together to activate PMS thus triply ensuring the copious production of •SO . Different from conventional ROS, the emergence of •SO , possessing a longer half-life and more rapid reaction, is independent of the oxygen (O ) and H O content within the tumor. In addition, this engineered nanosystem also exerts the function of photoacoustic imaging and skin restoration on the corresponding animal models. This study reveals the enormous potential of sulfate radical in oncotherapy and broadens pave for exploring the application of multifunctional and stimuli-responsive nanosystems in biomedicine.
变体模态通过利用来自外部或肿瘤内激励的激发来探索并合并到肿瘤纳米治疗中。然而，无处不在的缺氧和肿瘤微环境中过氧化氢 (H O ) 的含量不足不可避免地阻碍了活性氧物种 (ROS) 的有效产生。为了从束缚中彻底解脱出来，负载过一硫酸盐 (PMS: HSO ) 的中空介孔硫化铜 (CuS) 纳米粒子 (NPs) 被制备为独特的 ROS 供体，用于硫酸盐自由基 (•SO )介导和刺激响应的肿瘤纳米治疗，而无需氧气。在这种治疗模式中，第二近红外激光照射，以及释放的铜离子以及光照后 CuS 产生的热量，共同激活 PMS，从而三重确保大量产生•SO 。与传统的 ROS 不同，•SO 的出现具有更长的半衰期和更快的反应速度，与肿瘤内的氧气 (O ) 和 H O 含量无关。此外，该工程纳米系统还在相应的动物模型上发挥了光声成像和皮肤修复的功能。本研究揭示了硫酸盐在肿瘤治疗中的巨大潜力，并为探索多功能和刺激响应纳米系统在生物医学中的应用铺平了道路。
