Association of Dietary Inflammation Index and Immunoglobulin G Seropositivity in US Adults: A Population-Based Study.

BACKGROUND

Dietary patterns play important role in () infection. We aimed to investigate the potential relationship between Dietary Inflammation Index (DII) and infection in US adults.

METHODS

This cross-sectional study was based on National Health and Nutrition Examination Survey (1999-2000). Individuals aged ≥20 years who provided a 24 hr dietary intake history and underwent testing were included in the analysis. Multivariate weighted logistic regression analysis, smooth curve fitting, and subgroup analysis were used to investigate the relationship between DII and infection. Subgroup analyses were based on demographic and clinical variables.

RESULTS

There were 4,000 individuals enrolled in our final analysis. The overall mean age was 45.92 years and 46.77% were males. The overall prevalence of infection in the study population was 45.9%. The smooth curve fitting analysis indicated a near-linear relationship between DII and . In multivariate weighted logistic regression analysis, the odds ratio (OR) of DII is 1.17 (95% confidence interval (CI), 1.09-1.27) for infection. In subgroup analysis, DII still increased the risk of infection independently.

CONCLUSIONS

The increased DII levels were associated with an increased risk of infection among US adults. Further studies are needed to elucidate the exact mechanisms of DII and infection.