Department of Psychiatry College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia.
Afr Health Sci. 2023 Mar;23(1):231-240. doi: 10.4314/ahs.v23i1.25.
Depression is one of the most common mental health problems comorbid with tuberculosis. However, a consolidated picture of the prevalence of depression among tuberculosis patients in East Africa remains unknown. This systematic review and meta-analysis provide new understandings by systematically examining evidence concerning the prevalence of depression among tuberculosis patients in East Africa.
Literature was found in a database of HINARI, SCOPUS, PubMed, Science Direct, and Google Scholar. The Newcastle-Ottawa quality assessment scale was used to appraise the quality of the selected studies. Then, the DerSimonian and Laird random-effects model was applied because of the presence of heterogeneity among studies.
A total of 409 studies were accessed. However, only 29 qualified for a full-text review, and 9 studies with a population of 2838 were included in the qualitative description and quantitative analysis. The pooled prevalence estimate of depression amongst tuberculosis patients was 43.03 % (34.93, 51.13). The highest prevalence was observed in Kenya, with 45.71% (29.26, 62.16); a similar rate was observed in Ethiopia, with 45.11 % (34.60, 55.62). Subgroup analysis based on screening tool was used: 45.71% with BDI and 41.53% with PHQ.
抑郁症是与结核病共病的最常见精神健康问题之一。然而，东非结核病患者中抑郁症的患病率仍不明确。本系统评价和荟萃分析通过系统检查东非结核病患者中抑郁症患病率的证据，提供了新的认识。
在 HINARI、SCOPUS、PubMed、Science Direct 和 Google Scholar 数据库中查找文献。使用纽卡斯尔-渥太华质量评估量表来评估所选研究的质量。然后，由于研究之间存在异质性，应用了 DerSimonian 和 Laird 随机效应模型。
共查阅了 409 篇研究，但只有 29 篇符合全文审查标准，9 项研究纳入了 2838 例人群，进行了定性描述和定量分析。结核病患者中抑郁症的 pooled 患病率估计值为 43.03%（34.93, 51.13）。肯尼亚的患病率最高，为 45.71%（29.26, 62.16）；埃塞俄比亚的患病率相似，为 45.11%（34.60, 55.62）。根据筛查工具进行的亚组分析：BDI 为 45.71%，PHQ 为 41.53%。
