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年龄是决定家鸭对H5 2.3.2.1c分支和2.3.4.4e分支高致病性禽流感病毒易感性的一个因素。

Age is a determinant factor in the susceptibility of domestic ducks to H5 clade 2.3.2.1c and 2.3.4.4e high pathogenicity avian influenza viruses.

作者信息

Lee Sun-Hak, Lee Jiho, Noh Jin-Yong, Jeong Jei-Hyun, Kim Jun-Beom, Kwon Jung-Hoon, Youk Sungsu, Song Chang-Seon, Lee Dong-Hun

机构信息

Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.

KHAV Co., Ltd., Seoul, Republic of Korea.

出版信息

Front Vet Sci. 2023 Jul 20;10:1207289. doi: 10.3389/fvets.2023.1207289. eCollection 2023.

DOI:10.3389/fvets.2023.1207289
PMID:37546334
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10400362/
Abstract

High pathogenicity avian influenza (HPAI) is a viral disease with devastating consequences for the poultry industry worldwide. Domestic ducks are a major source of HPAI viruses in many Eurasian countries. The infectivity and pathogenicity of HPAI viruses in ducks vary depending on host and viral factors. To assess the factors influencing the infectivity and pathogenicity of HPAI viruses in ducks, we compared the pathobiology of two HPAI viruses (H5N1 clade 2.3.2.1c and H5N6 clade 2.3.4.4e) in 5- and 25-week-old ducks. Both HPAI viruses caused mortality in a dose-dependent manner (10, 10, and 10 EID) in young ducks. By contrast, adult ducks were infected but exhibited no mortality due to either virus. Viral excretion was higher in young ducks than in adults, regardless of the HPAI strain. These findings demonstrate the age-dependent mortality of clade 2.3.2.1c and clade 2.3.4.4e H5 HPAI viruses in ducks.

摘要

高致病性禽流感（HPAI）是一种对全球家禽业具有毁灭性后果的病毒性疾病。在许多欧亚国家，家鸭是HPAI病毒的主要来源。HPAI病毒在鸭中的传染性和致病性因宿主和病毒因素而异。为了评估影响HPAI病毒在鸭中传染性和致病性的因素，我们比较了两种HPAI病毒（H5N1 2.3.2.1c分支和H5N6 2.3.4.4e分支）在5周龄和25周龄鸭中的病理生物学。两种HPAI病毒在幼鸭中均以剂量依赖性方式（10、10和10 EID）导致死亡。相比之下，成年鸭受到感染，但两种病毒均未导致死亡。无论HPAI毒株如何，幼鸭的病毒排泄量均高于成年鸭。这些发现证明了2.3.2.1c分支和2.3.4.4e分支H5 HPAI病毒在鸭中存在年龄依赖性死亡率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aa9/10400362/e4e56dcd1fda/fvets-10-1207289-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aa9/10400362/9fc9265cea0a/fvets-10-1207289-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aa9/10400362/96a012eed510/fvets-10-1207289-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aa9/10400362/e4e56dcd1fda/fvets-10-1207289-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aa9/10400362/9fc9265cea0a/fvets-10-1207289-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aa9/10400362/96a012eed510/fvets-10-1207289-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aa9/10400362/e4e56dcd1fda/fvets-10-1207289-g003.jpg

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