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子宫切除术与肾癌风险有关吗？一项队列研究的荟萃分析。

Is hysterectomy associated with kidney cancer risk? A meta-analysis of cohort studies.

作者信息

Yu Ling, Yu Pengkui, Lu Yi

机构信息

Department of Urology, Shengzhou People's Hospital, Shengzhou Branch of the First Affiliated Hospital of Zhejiang University, Shengzhou, Zhejiang, China.

出版信息

Front Oncol. 2023 Jul 20;13:1181112. doi: 10.3389/fonc.2023.1181112. eCollection 2023.

DOI:10.3389/fonc.2023.1181112
PMID:37546408
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10397505/
Abstract

INTRODUCTION

Emerging evidence have suggested a potential relationship between hysterectomy and risk of kidney cancer with inconsistent results. We aimed to investigate the association of hysterectomy with kidney cancer risk based on a meta-analysis of all available cohort studies.

METHODS

A comprehensive literature search was performed in the PubMed and Embase database, covering all the papers published by September 2022. The pooled relative risks (RRs) and 95% confidence intervals (CIs) were estimated using a DerSimonian and Laird random effects model.

RESULTS

Overall, our meta-analysis included 10 cohorts from 9 studies with approximately 240 million participants. The pooled RR with its 95% CI showed a significantly positive association between hysterectomy and risk of kidney cancer (RR 1.30, 95% CI 1.19-1.41). No obvious heterogeneity was observed across the studies ( = 0.206 for heterogeneity; I = 25.9%).

CONCLUSION

Findings from this meta-analysis of cohort studies indicated that hysterectomy was positively associated with subsequent kidney cancer risk. Further large prospective studies with long-term follow-up are warranted to verify these findings.

摘要

引言

新出现的证据表明子宫切除术与肾癌风险之间可能存在关联，但结果并不一致。我们旨在通过对所有可用队列研究进行荟萃分析，来调查子宫切除术与肾癌风险之间的关联。

方法

在PubMed和Embase数据库中进行了全面的文献检索，涵盖截至2022年9月发表的所有论文。使用DerSimonian和Laird随机效应模型估计合并相对风险（RRs）和95%置信区间（CIs）。

结果

总体而言，我们的荟萃分析纳入了来自9项研究的10个队列，参与者约有2.4亿。合并RR及其95%CI显示子宫切除术与肾癌风险之间存在显著正相关（RR 1.30，95%CI 1.19 - 1.41）。各研究之间未观察到明显的异质性（异质性 = 0.206；I² = 25.9%）。

结论

这项队列研究的荟萃分析结果表明，子宫切除术与随后的肾癌风险呈正相关。需要进一步进行长期随访的大型前瞻性研究来验证这些发现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5913/10397505/998548624d0c/fonc-13-1181112-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5913/10397505/cce39c2d8c0b/fonc-13-1181112-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5913/10397505/93d435db4ac1/fonc-13-1181112-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5913/10397505/2be4220298fa/fonc-13-1181112-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5913/10397505/7f91de3711b7/fonc-13-1181112-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5913/10397505/998548624d0c/fonc-13-1181112-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5913/10397505/cce39c2d8c0b/fonc-13-1181112-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5913/10397505/93d435db4ac1/fonc-13-1181112-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5913/10397505/2be4220298fa/fonc-13-1181112-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5913/10397505/7f91de3711b7/fonc-13-1181112-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5913/10397505/998548624d0c/fonc-13-1181112-g005.jpg

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