Kim Siah, van Zwieten Anita, Wyld Melanie, Ladhani Maleeka, Guha Chandana, Dominello Amanda, Mallitt Kylie-Ann, Francis Anna, Mannon Roslyn B, Wong Germaine
Centre for Kidney Research, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.
Sydney School of Public Health, University of Sydney, Camperdown, New South Wales, Australia.
Kidney Int Rep. 2023 May 26;8(8):1553-1561. doi: 10.1016/j.ekir.2023.05.016. eCollection 2023 Aug.
Females account for 60% of all living kidney donors worldwide. We defined the proportion of female to male donors for living donor kidney transplantation stratified by recipient gender, and explored the factors associated with female kidney donation.
Data from the ANZDATA (Australian and New Zealand Dialysis and Transplantation) and ANZOD (Australian and New Zealand Organ Donor) registries (2002-2019) were used to identify the sociodemographic characteristics and their interactions associated with living donation from female donors. We derived the predicted probabilities from adjusted logistic models using marginal means.
Of 3523 living donor pairs, 2203 (63%) recipients were male, and 2012 (57%) donors were female. Male recipients were more likely to receive kidneys from female donors than male donors. Donor and recipient sex association was modified by donor-recipient relationship ( < 0.01), with sensitivity analysis suggesting that spousal donor-recipient pairs drive this interaction. Older recipients residing in regional or remote areas were more likely to receive kidneys from female donors compared with those from major cities (aged ≥60 years: 0.67 [0.63-0.71] vs. aged <60 years: 0.57 [0.53-0.60]).
Factors associated with female donation include recipient sex, with spousal donors contributing to the interaction between recipient gender and donor-recipient relationship. Recipient age and location of residence have interactive effects on the likelihood of living donor transplantation from female donors.
在全球所有活体肾供者中，女性占60%。我们确定了按受者性别分层的活体供肾移植中女性供者与男性供者的比例，并探讨了与女性肾捐赠相关的因素。
使用来自ANZDATA（澳大利亚和新西兰透析与移植）和ANZOD（澳大利亚和新西兰器官捐赠）登记处（2002 - 2019年）的数据，以确定与女性供者活体捐赠相关的社会人口统计学特征及其相互作用。我们使用边际均值从调整后的逻辑模型中得出预测概率。
在3523对活体供者中，2203名（63%）受者为男性，2012名（57%）供者为女性。男性受者比男性供者更有可能接受女性供者的肾脏。供者与受者的性别关联因供者 - 受者关系而改变（<0.01），敏感性分析表明配偶供受者对驱动了这种相互作用。与来自大城市的受者相比，居住在地区或偏远地区的老年受者更有可能接受女性供者的肾脏（年龄≥60岁：0.67[0.63 - 0.71] vs.年龄<60岁：0.57[0.53 - 0.60]）。
与女性捐赠相关的因素包括受者性别，配偶供者促成了受者性别与供者 - 受者关系之间的相互作用。受者年龄和居住地点对女性供者活体移植的可能性具有交互作用。
