Zahmatyar Mahdi, Fazlollahi Asra, Motamedi Alireza, Zolfi Maedeh, Seyedi Fatemeh, Nejadghaderi Seyed Aria, Sullman Mark J M, Mohammadinasab Reza, Kolahi Ali-Asghar, Arshi Shahnam, Safiri Saeid
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Neurosciences Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Front Med (Lausanne). 2023 Jul 20;10:1157670. doi: 10.3389/fmed.2023.1157670. eCollection 2023.
Human monkeypox is a zoonotic infection that is similar to the diseases caused by other poxviruses. It is endemic among wild rodents in the rainforests of Central and Western Africa, and can be transmitted via direct skin contact or mucosal exposure to infected animals. The initial symptoms include fever, headache, myalgia, fatigue, and lymphadenopathy, the last of which is the main symptom that distinguishes it from smallpox. In order to prevent and manage the disease, those who are infected must be rapidly diagnosed and isolated. Several vaccines have already been developed (e.g., JYNNEOS, ACAM2000 and ACAM3000) and antiviral drugs (e.g., cidofovir and tecovirimat) can also be used to treat the disease. In the present study, we reviewed the history, morphology, clinical presentations, transmission routes, diagnosis, prevention, and potential treatment strategies for monkeypox, in order to enable health authorities and physicians to better deal with this emerging crisis.
人类猴痘是一种人畜共患感染病，与其他痘病毒引起的疾病相似。它在中非和西非雨林的野生啮齿动物中呈地方性流行，可通过直接皮肤接触或黏膜接触感染动物进行传播。初始症状包括发热、头痛、肌痛、疲劳和淋巴结病，其中最后一项是将其与天花区分开来的主要症状。为预防和管理该疾病，必须对感染者进行快速诊断和隔离。已经研发了几种疫苗（例如，JYNNEOS、ACAM2000和ACAM3000），抗病毒药物（例如，西多福韦和替考韦玛）也可用于治疗该疾病。在本研究中，我们回顾了猴痘的历史、形态学、临床表现、传播途径、诊断、预防和潜在治疗策略，以便卫生当局和医生能够更好地应对这一新兴危机。
