Department of Dermatology, Panzhou People's Hospital, Panzhou, China.
Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
J Cosmet Dermatol. 2024 Jan;23(1):134-140. doi: 10.1111/jocd.15909. Epub 2023 Aug 7.
In Asia, axillary hyperhidrosis is a frequent problem for many people, and the consequent excessive sweating can seriously affect many aspects of daily life and even lead to mental disorders. Microwave therapy is a new, non-invasive treatment method for axillary hyperhidrosis, whose energy and long-term effectiveness still needs to be clinically validated.
The aim of this study was to evaluate the clinical efficacy, safety, histological changes, and psychological status of microwave devices in the treatment of axillary hyperhidrosis and osmidrosis.
We conducted a prospective self-controlled study in a top-tier Chinese hospital. After a 5/5 energy treatment session, a skin biopsy was taken to observe histological changes both before and after treatment. An iodine starch test was used to determine the sweating range. We evaluated symptoms of improved efficacy using the Hyperhidrosis Disease Severity Scale (HDSS) and assessed changes in life status with the DLQI. In the case of concurrent underarm odor, odor-5, VAS, and Young-Jin Park grading were used to assess odor relief. The effect of odor on psychology was assessed by using a psychological status symptom checklist (scl-90). The study period was 1 year.
We observed 20 patients in this study. Of those, 90% met the primary treatment endpoint of a decrease in axillary hyperhidrosis symptomatology to below grade 2 on the HDSS score (p < 0.001). Furthermore, 75% of patients achieved a treatment endpoint of at least 50% reduction in VAS (p < 0.001). 70% of patients achieved a treatment endpoint of at least 50% reduction in odor-5 (p < 0.001). The iodine starch test showed that the region decreased 99% from the baseline to 12 months after follow-up had ended (p < 0.001). Eight patients volunteered to undergo histological examination; their average light density of immunohistochemistry decreased from 1.04 (0.4-2.11) to 0.07 (0.04-0.46; p < 0.05). The immunohistochemical positive number for sweat glands was initially 104 (59.75-132.5) but was 41.5 (29.75-62) after the procedure. None of the patients experienced any serious adverse reactions.
The treatment demonstrated high effectiveness, safety, and short-lived adverse reactions.
在亚洲，腋窝多汗症是许多人的一个常见问题，由此导致的过度出汗会严重影响日常生活的许多方面，甚至导致精神障碍。微波治疗是一种治疗腋窝多汗症的新的非侵入性治疗方法，其能量和长期效果仍需要临床验证。
本研究旨在评估微波设备治疗腋窝多汗症和腋臭的临床疗效、安全性、组织学变化和心理状态。
我们在中国一家顶尖医院进行了一项前瞻性自身对照研究。在进行 5/5 能量治疗后，取皮肤活检观察治疗前后的组织学变化。采用碘淀粉试验确定出汗范围。我们使用多汗症疾病严重程度量表 (HDSS) 评估症状改善的疗效，并使用 DLQI 评估生活状况的变化。对于同时存在腋窝异味的患者，使用异味-5、VAS 和 Young-Jin Park 分级评估异味缓解情况。使用心理状态症状检查表 (scl-90) 评估异味对心理的影响。研究期间为 1 年。
本研究观察了 20 例患者。其中，90%的患者达到了 HDSS 评分中腋窝多汗症症状减轻至 2 级以下的主要治疗终点(p<0.001)。此外，75%的患者达到了 VAS 至少减少 50%的治疗终点(p<0.001)。70%的患者达到了异味-5 至少减少 50%的治疗终点(p<0.001)。碘淀粉试验显示，随访结束后 12 个月时，该区域从基线减少了 99%(p<0.001)。8 名患者自愿接受组织学检查；他们的免疫组化平均光密度从 1.04(0.4-2.11)降至 0.07(0.04-0.46;p<0.05)。汗腺的免疫组化阳性数最初为 104(59.75-132.5)，但在手术后为 41.5(29.75-62)。所有患者均未出现严重不良反应。
该治疗方法具有高效、安全、短暂不良反应的特点。
