School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
Phytomedicine. 2023 Oct;119:154978. doi: 10.1016/j.phymed.2023.154978. Epub 2023 Jul 17.
Microbiomes and their host plants are closely linked with each other; for example, the microbiome affects plant growth, fitness, nutrient uptake, stress tolerance and pathogen resistance, whereas the host plant supports the photosynthetically carbon-rich nutrition of the microbiome. The importance of the microbiome in plant‒soil ecosystems is unquestioned and has expanded to influence the medicinal application of some herbal plants via the gut microbiota.
Herbal plant-microbiome interactions may provide novel knowledge to enhance the robustness of herbal plant crop performance and medicinal applications, which requires a systematic review and preceding discussion.
The interactions between Panax notoginseng and microorganisms (from soil to host) were reviewed from the literature. The terms "Panax notoginseng" and "microbiota" were used in combination with the keywords "microbiota/microbes", "bacteria/bacterium" or "fungi/fungus" or "endophyte", as well as our targeted bioactive phytochemicals, including saponins and ginsenosides.
Our study focuses on the famous medicinal herb Panax notoginseng F. H. Chen and proposes that the microbiota is a crucial participant not only in the cultivation of this herbal plant but also in its medicinal application. We also summarize and discuss how these plant‒microbe co-associations shape the assembly of plant-related microbiomes and produce bioactive phytochemicals, as well as influence beneficial herbal traits, such as herbal plant health and pharmacology. In addition, we also highlight future directions.
The rhizosphere and endophytic microbiome of Panax notoginseng are indirectly or directly involved in plant health, biomass production, and the synthesis/biotransformation of plant secondary metabolites. Harnessing the microbiome to improve the quality of traditional Chinese medicine and improve the value of medicinal plants for human health is highly promising.
微生物组及其宿主植物密切相关；例如，微生物组影响植物的生长、适应性、养分吸收、抗逆性和抗病性，而宿主植物则为微生物组提供富含光合作用碳的营养物质。微生物组在植物-土壤生态系统中的重要性是毋庸置疑的，它已经扩展到通过肠道微生物群影响一些草药植物的药用应用。
草药植物-微生物组的相互作用可能为提高草药植物作物性能和药用应用的稳健性提供新的知识，这需要进行系统的综述和讨论。
从文献中综述了三七与微生物（从土壤到宿主）的相互作用。使用了“三七”和“微生物群”这两个术语，并与“微生物群/微生物”、“细菌/细菌”或“真菌/真菌”或“内生菌”以及我们的靶向生物活性植物化学物质（包括皂苷和人参皂苷）等关键词结合使用。
我们的研究集中在著名的药用植物三七上，并提出微生物群不仅是这种草药植物栽培的关键参与者，也是其药用应用的关键参与者。我们还总结和讨论了这些植物-微生物的共同关联如何塑造与植物相关的微生物组的组装，并产生生物活性植物化学物质，以及影响有益的草药特性，如草药植物的健康和药理学。此外，我们还强调了未来的方向。
三七的根际和内生微生物群间接或直接参与植物的健康、生物量生产以及植物次生代谢物的合成/生物转化。利用微生物组来提高中药的质量和提高药用植物对人类健康的价值是非常有前途的。
