Department of Plastic and Maxillofacial Surgery, The Royal Children's Hospital, Melbourne, Victoria, Australia.
Department of Genetics, Mercy Hospital for Women, Melbourne, Victoria, Australia.
Prenat Diagn. 2023 Sep;43(10):1310-1319. doi: 10.1002/pd.6418. Epub 2023 Aug 8.
Cleft lip and/or palate (CL/CP) is the most common congenital craniofacial anomaly and parents often ask, "how did this happen?" Patients and families may benefit from access to a multidisciplinary team (MDT) from prenatal diagnosis into early adulthood. Multiple factors can contribute to the development of a cleft. We discuss the epidemiology and risk factors that increase the likelihood of having a newborn with a cleft. The purpose of this article is to review the prenatal investigations involved in the diagnosis and workup of these patients in addition to postpartum treatment, prognostic factors, and counseling families regarding future recurrence risk.
唇腭裂（CL/CP）是最常见的颅面先天畸形，家长常问“这是怎么发生的？”患者及其家庭可能受益于多学科团队（MDT）从产前诊断到成年早期的服务。多个因素可导致唇腭裂的发生。我们讨论增加新生儿发生唇腭裂可能性的流行病学和危险因素。本文的目的是回顾产前检查在这些患者的诊断和评估中的作用，以及产后治疗、预后因素，并向家属提供有关未来复发风险的咨询。
