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与海水中游泳相关的原发性阿米巴脑膜脑炎病例。

A primary amoebic meningoencephalitis case associated with swimming in seawater.

机构信息

Department of Laboratory Medicine, The First Affiliated Hospital of Ningbo University, Ningbo University, Ningbo, China.

School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, 548 Binwen Road, Zhejiang, Hangzhou, China.

出版信息

Parasitol Res. 2023 Oct;122(10):2451-2452. doi: 10.1007/s00436-023-07934-z. Epub 2023 Aug 9.

DOI:10.1007/s00436-023-07934-z
PMID:37555856
Abstract

This case report describes a 62-year-old male fisherman who presented with persistent vomiting, headache, and behavior changes. Despite initial antibiotic and corticosteroid treatment, his condition worsened, leading to coma and subsequent death. Macro-genome sequencing of cerebrospinal fluid (CSF) revealed the presence of Naegleria fowleri infection, which had been missed during initial laboratory tests. The patient's exposure history included sea-swimming near Zhoushan Island.

摘要

本病例报告描述了一位 62 岁男性渔民,他出现持续性呕吐、头痛和行为改变。尽管最初接受了抗生素和皮质类固醇治疗,但他的病情恶化,导致昏迷并最终死亡。对脑脊液(CSF)进行宏基因组测序显示存在福氏耐格里阿米巴感染,这在最初的实验室检测中被遗漏了。患者的暴露史包括在舟山岛附近的海水中游泳。

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本文引用的文献

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Successful Treatment of Primary Amoebic Meningoencephalitis Using a Novel Therapeutic Regimen Including Miltefosine and Voriconazole.采用米替福新和伏立康唑新治疗方案成功治疗原发性阿米巴脑膜脑炎。
Acta Parasitol. 2022 Sep;67(3):1421-1424. doi: 10.1007/s11686-022-00591-9. Epub 2022 Jul 21.
2
Identification and molecular typing of Naegleria fowleri from a patient with primary amebic meningoencephalitis in China.从中国原发性阿米巴脑膜脑炎患者中鉴定和分子分型福氏耐格里阿米巴。
Int J Infect Dis. 2018 Jul;72:28-33. doi: 10.1016/j.ijid.2018.05.001. Epub 2018 May 8.
3
Surviving Naegleria fowleri infections: A successful case report and novel therapeutic approach.
福氏耐格里虫感染存活:成功病例报告及新型治疗方法。
Travel Med Infect Dis. 2017 Mar-Apr;16:49-51. doi: 10.1016/j.tmaid.2016.12.005. Epub 2016 Dec 22.
4
Fatal consequences of freshwater pearl diving.淡水珍珠潜水的致命后果。
Lancet. 2013 Jan 12;381(9861):176. doi: 10.1016/S0140-6736(12)61730-9.
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Primary amoebic meningo-encephalitis: clinical, pathological and epidemiological features of six fatal cases.原发性阿米巴脑膜脑炎:6例死亡病例的临床、病理及流行病学特征
J Pathol Bacteriol. 1968 Jul;96(1):1-25. doi: 10.1002/path.1700960102.