Wu Kai, Saha Renata, Su Diqing, Krishna Venkatramana D, Liu Jinming, Cheeran Maxim C-J, Wang Jian-Ping
Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Department of Chemical Engineering and Material Science, University of Minnesota, Minneapolis, Minnesota 55455, United States.
ACS Appl Nano Mater. 2020 Sep 22;3(10):9560-9580. doi: 10.1021/acsanm.0c02048. eCollection 2020 Oct 23.
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), is a threat to the global healthcare system and economic security. As of July 2020, no specific drugs or vaccines are yet available for COVID-19; a fast and accurate diagnosis for SARS-CoV-2 is essential in slowing the spread of COVID-19 and for efficient implementation of control and containment strategies. Magnetic nanosensing is an emerging topic representing the frontiers of current biosensing and magnetic areas. The past decade has seen rapid growth in applying magnetic tools for biological and biomedical applications. Recent advances in magnetic nanomaterials and nanotechnologies have transformed current diagnostic methods to nanoscale and pushed the detection limit to early-stage disease diagnosis. Herein, this review covers the literature of magnetic nanosensors for virus and pathogen detection before COVID-19. We review popular magnetic nanosensing techniques including magnetoresistance, magnetic particle spectroscopy, and nuclear magnetic resonance. Magnetic point-of-care diagnostic kits are also reviewed aiming at developing plug-and-play diagnostics to manage the SARS-CoV-2 outbreak as well as preventing future epidemics. In addition, other platforms that use magnetic nanomaterials as auxiliary tools for enhanced pathogen and virus detection are also covered. The goal of this review is to inform the researchers of diagnostic and surveillance platforms for SARS-CoV-2 and their performances.
新型严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引发了2019冠状病毒病（COVID-19），对全球医疗体系和经济安全构成威胁。截至2020年7月，尚无针对COVID-19的特效药物或疫苗；快速准确地诊断SARS-CoV-2对于减缓COVID-19的传播以及有效实施防控策略至关重要。磁性纳米传感是一个新兴领域，代表了当前生物传感和磁性领域的前沿。在过去十年中，磁性工具在生物和生物医学应用中的应用迅速增长。磁性纳米材料和纳米技术的最新进展将当前的诊断方法提升到了纳米尺度，并将检测限推进到早期疾病诊断。在此，本综述涵盖了COVID-19之前用于病毒和病原体检测的磁性纳米传感器的文献。我们回顾了流行的磁性纳米传感技术，包括磁阻、磁性颗粒光谱和核磁共振。还对磁性即时诊断试剂盒进行了综述，旨在开发即插即用诊断方法以应对SARS-CoV-2疫情并预防未来的流行病。此外，还涵盖了其他将磁性纳米材料用作增强病原体和病毒检测辅助工具的平台。本综述的目的是向研究人员介绍SARS-CoV-2的诊断和监测平台及其性能。
