Surgery Department, Veterinary Specialists & Emergency Services, Rochester, NY, United States of America.
PLoS One. 2023 Aug 9;18(8):e0289827. doi: 10.1371/journal.pone.0289827. eCollection 2023.
The aim of this study was to determine the effect of oclacitinib (Apoquel) on development of surgical site infections in canines following clean orthopedic stifle surgery. Medical records of dogs undergoing unilateral, clean orthopedic stifle procedures were retrospectively examined for development of post-operative surgical site infections. Data collected for statistical analysis included age, sex, body weight, current medications, anesthesia and surgery times, white blood cell count, and neutrophil count. Surgical site infections were identified in 8.7% (34/390) of stifle procedures- 8.0% (29/364) in dogs not treated with oclacitinib and 19.2% (5/26) in dogs treated with oclacitinib (p = 0.053). There was a significant difference in development of surgical site infection in dogs with longer anesthesia times (p = 0.003) and higher body weights (p = 0.037). Dogs being treated with oclacitinib at the time of clean, orthopedic stifle surgery did not have a significantly higher incidence of surgical site infections. However, client education regarding risk of infection and increased patient monitoring post-operatively are recommended, especially in patients with increased body weight or longer anesthetic times.
本研究旨在确定奥卡替尼（Apoquel）对行清洁骨科膝关节手术后犬发生手术部位感染的影响。对接受单侧清洁骨科膝关节手术的犬的医疗记录进行回顾性检查，以确定是否发生术后手术部位感染。用于统计分析的数据包括年龄、性别、体重、当前用药、麻醉和手术时间、白细胞计数和中性粒细胞计数。390 例膝关节手术中，有 8.7%（34/390）发生手术部位感染——未使用奥卡替尼的犬中 8.0%（29/364）发生手术部位感染，使用奥卡替尼的犬中 19.2%（5/26）发生手术部位感染（p = 0.053）。麻醉时间较长（p = 0.003）和体重较高（p = 0.037）的犬发生手术部位感染的差异有统计学意义。在清洁骨科膝关节手术时使用奥卡替尼的犬，手术部位感染的发生率没有显著升高。但是，建议对感染风险进行客户教育，并在术后增加对患者的监测，特别是在体重较高或麻醉时间较长的患者中。
