Martins Isabel Silva, de Vasconcelos Natália Pestana, Afonso Américo Santos, Braga Ana Cristina, Pina-Vaz Irene
Faculty of Dental Medicine, University of Porto, 4200-393, Porto, Portugal.
Faculty of Medicine, CINTESIS, University of Porto, 4200-319, Porto, Portugal.
Odontology. 2025 May 19. doi: 10.1007/s10266-025-01122-4.
Alcohol consumption is linked to reduced bone mass and strength due to an imbalance in bone remodeling, characterized by decreased bone formation and an increased inflammatory response. Apical periodontitis affects the tissues surrounding the teeth and may also influence the systemic immune response by altering inflammatory marker levels. This systematic review examined how alcohol consumption affects the severity of experimental apical periodontitis in animal models. Following PRISMA guidelines, studies were sourced from three databases (PubMed, Scopus, and Web of Science) up to January 26, 2025. The included studies analyzed inflammation and/or bone resorption in animals with induced apical periodontitis, comparing alcohol-exposed groups to well-defined controls. Study quality was evaluated using the Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines and the risk of bias was analyzed using the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool. Of 135 screened records, 7 studies met the inclusion criteria. These studies were of moderate quality with a moderate risk of bias. Findings revealed that chronic alcohol consumption exacerbates inflammation and bone resorption in rats with experimental apical periodontitis, with effects increasing in a dose-dependent manner. The evidence suggests that chronic alcohol consumption amplifies the periapical inflammatory response in animal models, potentially accelerating apical periodontitis progression. These results highlight the need for further prospective studies to explore the broader implications of alcohol consumption in the context of apical periodontitis. This systematic review is registered on the International Prospective Register of Systematic Reviews (PROSPERO; CRD42024589226).
饮酒与骨量和骨强度降低有关，这是由于骨重塑失衡所致，其特征是骨形成减少和炎症反应增加。根尖周炎会影响牙齿周围的组织，还可能通过改变炎症标志物水平来影响全身免疫反应。本系统评价研究了饮酒如何影响动物模型中实验性根尖周炎的严重程度。按照PRISMA指南，截至2025年1月26日，从三个数据库（PubMed、Scopus和Web of Science）中获取研究。纳入的研究分析了诱导性根尖周炎动物的炎症和/或骨吸收情况，将饮酒暴露组与明确的对照组进行比较。使用《动物研究：体内实验报告》（ARRIVE）指南评估研究质量，并使用实验室动物实验系统评价中心（SYRCLE）工具分析偏倚风险。在筛选的135条记录中，有7项研究符合纳入标准。这些研究质量中等，存在中等偏倚风险。研究结果显示，慢性饮酒会加剧实验性根尖周炎大鼠的炎症和骨吸收，且作用呈剂量依赖性增加。证据表明，慢性饮酒会放大动物模型中的根尖周炎症反应，可能加速根尖周炎的进展。这些结果凸显了进一步进行前瞻性研究的必要性，以探讨饮酒在根尖周炎背景下的更广泛影响。本系统评价已在国际系统评价前瞻性注册库（PROSPERO；CRD42024589226）上注册。
