Ye Guoguo, Xu Zhixiang, Yang Minghui, Wang Jun, Liang Jinhu, Yin Juzhen, Yang Yang, Xia Han, Liu Yingxia
Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, Division of Infectious Disease,The Third People's Hospital of Shenzhen, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, China.
School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Comput Struct Biotechnol J. 2023 Jul 8;21:3728-3735. doi: 10.1016/j.csbj.2023.07.001. eCollection 2023.
Dengue fever (DF) and dengue hemorrhagic fever (DHF) are among the most common tropical diseases affecting humans. To analyze the risk of clinical and transmission of DF/DHF in Shenzhen, the surveillance on patients of all-age patients with dengue virus (DENV) infections was conducted. Our findings revealed that the majority of DENV-infected patients are young to middle-aged males, and the development of the disease is accompanied by abnormal changes in the percentages of neutrophils, lymphocytes, and basophils. Demographic analysis revealed that these patients is concentrated in areas such as Futian District, which may be due to the higher mosquito density and temperature than that in other area. Subsequent, mosquito infection experiments confirmed that the effect of temperature shift on DENV proliferation and transmission. Not only that, constant temperatures can enhance the spread of DENV, even increase the risk of epidemic. Thus, the role of innate immune response should be highlighted in the prediction of severe severity of DENV-infected patients, and temperature should be taken into account in the prevention and control of DENV.
Dengue fever (DF) and dengue hemorrhagic fever (DHF) are among the most common tropical diseases affecting humans, and which caused by the four dengue virus serotypes (DENV 1-4).
To analyze the risk of clinical and transmission of DF/DHF in Shenzhen.
The surveillance on patients of all-age patients with dengue virus (DENV) infections was conducted.
Our findings revealed that the majority of DENV-infected patients are young to middle-aged males, and the development of the disease is accompanied by abnormal changes in the percentages of neutrophils, lymphocytes, and basophils. Demographic analysis revealed that these patients is concentrated in areas such as Futian District, which may be due to the higher mosquito density and temperature than that in other area. Subsequent, mosquito infection experiments confirmed that the effect of temperature shift on DENV proliferation and transmission. Not only that, constant temperatures can enhance the spread of DENV, even increase the risk of epidemic.
登革热（DF）和登革出血热（DHF）是影响人类的最常见热带疾病。为分析深圳登革热/登革出血热的临床和传播风险，对所有年龄段登革病毒（DENV）感染患者进行了监测。我们的研究结果显示，大多数DENV感染患者为中青年男性，疾病发展伴随着中性粒细胞、淋巴细胞和嗜碱性粒细胞百分比的异常变化。人口统计学分析显示，这些患者集中在福田区等地区，这可能是由于这些地区蚊虫密度和温度高于其他地区。随后，蚊虫感染实验证实了温度变化对DENV增殖和传播的影响。不仅如此，恒温可促进DENV传播，甚至增加流行风险。因此，在预测DENV感染患者的严重程度时应突出先天免疫反应的作用，在DENV的防控中应考虑温度因素。
登革热（DF）和登革出血热（DHF）是影响人类的最常见热带疾病，由四种登革病毒血清型（DENV 1-4）引起。
分析深圳登革热/登革出血热的临床和传播风险。
对所有年龄段登革病毒（DENV）感染患者进行监测。
我们的研究结果显示，大多数DENV感染患者为中青年男性，疾病发展伴随着中性粒细胞、淋巴细胞和嗜碱性粒细胞百分比的异常变化。人口统计学分析显示，这些患者集中在福田区等地区，这可能是由于这些地区蚊虫密度和温度高于其他地区。随后，蚊虫感染实验证实了温度变化对DENV增殖和传播的影响。不仅如此，恒温可促进DENV传播，甚至增加流行风险。
