Cui Yuliang, Qu Zhenzhen, Hu Wenmei, Shi Haiyan
Department of Endocrinology, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou 253000, China.
Int J Endocrinol. 2023 Aug 1;2023:2513175. doi: 10.1155/2023/2513175. eCollection 2023.
To investigate the relationship between uric acid to high-density lipoprotein cholesterol ratio (UHR) levels and nonalcoholic fatty liver disease (NAFLD) in nonoverweight/obese patients with type 2 diabetes.
A retrospective study was designed including a total of 343 inpatients with type 2 diabetes whose BMI<24 kg/m. The population was divided into three groups as the UHR tertiles. Logistic regression analysis was performed to estimate odds ratios (ORs) of UHR for NAFLD. ROC curve analysis was used to estimate the diagnostic value of UHR for NAFLD.
The prevalence rat of NAFLD enhanced progressively from the tertile 1 to tertile 3 of UHR (30.70% vs. 56.52% vs. 73.68%). Logistic regression analysis showed that participants in the higher UHR groups, compared with those in the first tertile group, had higher occurrence risks for NAFLD. The positive association between UHR and NAFLD was independent of age, BMI, blood pressure, hepatic enzymes, and other components of metabolic disorders. ROC curve analysis showed that the area under curve (AUC), sensitivity, and specificity for UHR were 0.697, 0.761, and 0.553, respectively.
In type 2 diabetic patients without overweight or obesity, UHR is significantly associated with NAFLD and can be used as a novel and useful predictor for NAFLD onset.
探讨非超重/肥胖的2型糖尿病患者尿酸与高密度脂蛋白胆固醇比值（UHR）水平与非酒精性脂肪性肝病（NAFLD）之间的关系。
设计一项回顾性研究，纳入343例BMI<24kg/m²的2型糖尿病住院患者。将研究人群按UHR三分位数分为三组。采用逻辑回归分析评估UHR对NAFLD的比值比（OR）。采用受试者工作特征曲线（ROC曲线）分析评估UHR对NAFLD的诊断价值。
NAFLD的患病率从UHR三分位数第1组到第3组逐渐升高（30.70%对56.52%对73.68%）。逻辑回归分析显示，与第一三分位数组相比，UHR较高组的参与者患NAFLD的风险更高。UHR与NAFLD之间的正相关独立于年龄、BMI、血压、肝酶及其他代谢紊乱成分。ROC曲线分析显示，UHR的曲线下面积（AUC）、敏感性和特异性分别为0.697、0.761和0.553。
在无超重或肥胖的2型糖尿病患者中，UHR与NAFLD显著相关，可作为NAFLD发病的一种新的有用预测指标。
