Vorontsov I V, Moshiashvili I Ia, Severtsova M K, Besova S A
Zh Mikrobiol Epidemiol Immunobiol. 1979 Apr(4):62-6.
The work deals with the study of the possibility of using the passive hemagglutination inhibition test (antibody neutralization) for the determination of the antigenic activity of botulinum toxoids, types A, B and E. Erythrocytic diagnostic preparations were shown to allow the determination of up to 0.1 g of antigen. At the same time in vitro determinations were found to satisfactorily correlate with the results of in vivo determinations of the antigenic activity of these toxoids in the antitoxin-fixation test.
该研究致力于探讨使用被动血凝抑制试验（抗体中和）来测定A、B和E型肉毒类毒素抗原活性的可能性。结果表明，红细胞诊断制剂能够测定低至0.1微克的抗原。同时，体外测定结果与这些类毒素在抗毒素固定试验中的体内抗原活性测定结果具有良好的相关性。
