Song Jukun, Wu Yadong, Yin Xinhai, Zhang Junmei
Department of Oral and Maxillofacial Surgery the Affiliated Stomatological Hospital of Guizhou Medical University Guiyang China.
Department of Oral and Maxillofacial Surgery Guizhou Provincial People's Hospital Guiyang China.
Health Sci Rep. 2023 Aug 8;6(8):e1413. doi: 10.1002/hsr2.1413. eCollection 2023 Aug.
Coronavirus disease (COVID-19) is a major danger to world health and has been linked to periodontitis in a number of epidemiological observational studies. However, it is unclear whether COVID-19 causes periodontitis. COVID-19's causal influence on periodontitis was determined using bidirectional Mendelian randomization (MR).
Large-scale COVID-19 and periodontitis genome wide association study data were analyzed. Inverse variance weighting, MR-Egger, weighted median, and MR-PRESSO were used to estimate causal effects. Sensitivity studies were conducted using the Cochran's Q test, the MR-Egger intercept test, the MR-PRESSO, and the leave-one-out (LOO) analysis. Further investigation of potential mediating factors was performed using risk factor analysis.
The MR presented no causal relationship between periodontitis and hospitalization for COVID-19 (odds ratio [OR] = 0.97, 95% confidence interval [CI] 0.78-1.20; = 0.76), vulnerability to COVID-19 (OR = 1.04, 95% CI 0.88-1.21; = 0.65), COVID-19 disease severity (OR = 1.01, 95% CI 0.92-1.11; = 0.81). Meanwhile, a noncausal effect of genetic hospitalization for COVID-19, illness severity, and vulnerability to periodontitis was detected. Other MR methods yielded identical results to inverse variance weighting. According to sensitivity analysis, horizontal pleiotropy is unlikely to affect causal estimation.
Periodontitis had no link to the risk of COVID-19 hospitalization, susceptibility, or severity. However, the substance in COVID-19 that is responsible for this effect must be studied further.
冠状病毒病（COVID-19）是对全球健康的重大威胁，多项流行病学观察性研究已将其与牙周炎联系起来。然而，尚不清楚COVID-19是否会导致牙周炎。采用双向孟德尔随机化（MR）确定COVID-19对牙周炎的因果影响。
分析了大规模COVID-19和牙周炎全基因组关联研究数据。采用逆方差加权、MR-Egger、加权中位数和MR-PRESSO估计因果效应。使用 Cochr an's Q检验、MR-Egger截距检验、MR-PRESSO和留一法（LOO）分析进行敏感性研究。通过危险因素分析进一步调查潜在的中介因素。
MR显示牙周炎与COVID-19住院治疗（优势比[OR]=0.97，95%置信区间[CI]0.78-1.20；P=0.76）、对COVID-19的易感性（OR=1.04，95%CI 0.88-1.21；P=0.65）、COVID-19疾病严重程度（OR=1.01，95%CI 0.92-1.11；P=0.81）之间无因果关系。同时，检测到COVID-19基因住院治疗、疾病严重程度和对牙周炎易感性的非因果效应。其他MR方法产生了与逆方差加权相同的结果。根据敏感性分析，水平多效性不太可能影响因果估计。
牙周炎与COVID-19住院风险、易感性或严重程度无关。然而，导致这种效应的COVID-19中的物质必须进一步研究。
