Salamat Mohammad Reza, Momeni Shokouh, Rastegari Ali Asghar
Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Molecular and Cell Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, Iran.
Adv Biomed Res. 2023 Jun 30;12:162. doi: 10.4103/abr.abr_135_22. eCollection 2023.
Osteoporosis is the most prevalent metabolic bone disease in postmenopausal women associated with reduced bone mass and increased bone fracture. Measuring bone density in the lumbar spine and hip is a reliable measure of bone mass and can therefore specify the risk of fracture. Dual-energy X-ray absorptiometry (DXA) is an accurate non-invasive system measuring bone density, with a low margin of error and no complications. The present study aimed to investigate the relationship between biochemical parameters with bone density in postmenopausal women.
This cross-sectional study was conducted on 87 postmenopausal women referred to osteoporosis centers in Isfahan. Bone density was measured in the spine and hip area using the DXA system. Serum levels of calcium, phosphorus, alkaline phosphatase, and magnesium were measured by an autoanalyzer, and serum levels of vitamin D were measured by high-performance liquid chromatography (HPLC).
The mean parameters of calcium, phosphorus, alkaline phosphatase, vitamin D, and magnesium did not show a significant difference between the two groups (-value > 0.05). In the control group, the relationship between alkaline phosphatase and bone mineral content (BMC) and bony area (BA) in the spine was significant with a correlation coefficient of - 0.402 and 0.258, respectively (P-value < 0.05) and BMD and T-score in the femoral neck area showed a direct and significant relationship with phosphorus (correlation = 0.368; value = 0.038). There was a significant relationship between the Z-score with calcium (correlation = 0.358; value = 0.044).
There was no significant relationship between the values of calcium, phosphorus, alkaline phosphatase, vitamin D, and magnesium parameters and bone density (spine and hip) in postmenopausal women with osteopenia or osteoporosis.
骨质疏松症是绝经后女性中最常见的代谢性骨病，与骨量减少和骨折风险增加相关。测量腰椎和髋部的骨密度是骨量的可靠指标，因此可以确定骨折风险。双能X线吸收法（DXA）是一种准确的非侵入性骨密度测量系统，误差小且无并发症。本研究旨在探讨绝经后女性生化参数与骨密度之间的关系。
本横断面研究对87名转诊至伊斯法罕骨质疏松症中心的绝经后女性进行。使用DXA系统测量脊柱和髋部区域的骨密度。通过自动分析仪测量血清钙、磷、碱性磷酸酶和镁水平，通过高效液相色谱法（HPLC）测量血清维生素D水平。
两组之间钙、磷、碱性磷酸酶、维生素D和镁的平均参数无显著差异（P值>0.05）。在对照组中，脊柱碱性磷酸酶与骨矿物质含量（BMC）和骨面积（BA）之间的关系显著，相关系数分别为-0.402和0.258（P值<0.05），股骨颈区域的骨密度（BMD）和T值与磷呈直接显著关系（相关性=0.368；P值=0.038）。Z值与钙之间存在显著关系（相关性=0.358；P值=0.044）。
在患有骨质减少或骨质疏松症的绝经后女性中，钙、磷、碱性磷酸酶、维生素D和镁参数值与骨密度（脊柱和髋部）之间无显著关系。
