Department/Institute of Neurobiology, School of Basic Medical Science, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Department of Human Anatomy & Histoembryology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Cells. 2023 Jul 27;12(15):1942. doi: 10.3390/cells12151942.
The interaction between microglia and astrocytes exhibits a relatively balanced state in order to maintain homeostasis in the healthy central nervous system (CNS). Disease stimuli alter microglia-astrocyte interaction patterns and elicit cell-type-specific responses, resulting in their contribution to various pathological processes. Here, we review the similarities and differences in the activation modes between microglia and astrocytes in various scenarios, encompassing different stages of neural development and a wide range of neural disorders. The aim is to provide a comprehensive understanding of their roles in neural development and regeneration and guiding new strategies for restoring CNS homeostasis.
小胶质细胞和星形胶质细胞之间的相互作用呈现出相对平衡的状态，以维持健康中枢神经系统（CNS）的内稳态。疾病刺激改变了小胶质细胞-星形胶质细胞相互作用模式，并引发了细胞类型特异性反应，导致它们参与各种病理过程。在这里，我们综述了小胶质细胞和星形胶质细胞在各种情况下激活模式的异同，包括神经发育的不同阶段和广泛的神经疾病。目的是全面了解它们在神经发育和再生中的作用，并为恢复中枢神经系统内稳态提供新的策略。
