小胶质细胞作为大脑功能的动态细胞介体。
Microglia as Dynamic Cellular Mediators of Brain Function.
机构信息
Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
出版信息
Trends Mol Med. 2019 Nov;25(11):967-979. doi: 10.1016/j.molmed.2019.08.013. Epub 2019 Oct 6.
Abstract
Originally hypothesized to function solely as immunologic responders within the central nervous system (CNS), emerging evidence has revealed that microglia have more complex roles in normal brain development and in the context of disease. In health, microglia influence neural progenitor fate decisions, astrocyte activation, neuronal homeostasis, and synaptogenesis. In the setting of brain disease, including autism, brain tumors, and neurodegenerative disorders, microglia undergo substantial morphological, molecular, and functional changes, which establish new biological states relevant to disease pathogenesis and progression. In this review, we discuss the function of microglia in health and disease and outline a conceptual framework for elucidating their specific contributions to nervous system pathobiology.
摘要
最初假设仅在中枢神经系统 (CNS) 中作为免疫反应者发挥作用，新出现的证据表明，小胶质细胞在正常大脑发育和疾病背景下具有更复杂的作用。在健康状态下，小胶质细胞影响神经祖细胞命运决定、星形胶质细胞激活、神经元内稳态和突触发生。在包括自闭症、脑肿瘤和神经退行性疾病在内的脑部疾病中，小胶质细胞发生显著的形态、分子和功能变化，建立了与疾病发病机制和进展相关的新的生物学状态。在这篇综述中，我们讨论了小胶质细胞在健康和疾病中的功能，并概述了阐明它们对神经系统病理生物学具体贡献的概念框架。
相似文献
1
Microglia as Dynamic Cellular Mediators of Brain Function.小胶质细胞作为大脑功能的动态细胞介体。
Trends Mol Med. 2019 Nov;25(11):967-979. doi: 10.1016/j.molmed.2019.08.013. Epub 2019 Oct 6.
2
Are circulating monocytes as microglia orthologues appropriate biomarker targets for neuronal diseases?循环单核细胞作为小胶质细胞的直系同源物，是否是神经元疾病合适的生物标志物靶点？
Cent Nerv Syst Agents Med Chem. 2009 Dec;9(4):307-30. doi: 10.2174/187152409789630424.
3
Microglia: Housekeeper of the Central Nervous System.小胶质细胞：中枢神经系统的管家。
Cell Mol Neurobiol. 2018 Jan;38(1):53-71. doi: 10.1007/s10571-017-0504-2. Epub 2017 May 22.
4
[The Role of Microglia in the Homeostasis of the Central Nervous System and Neuroinflammation].[小胶质细胞在中枢神经系统稳态和神经炎症中的作用]
Mol Biol (Mosk). 2019 Sep-Oct;53(5):790-798. doi: 10.1134/S0026898419050057.
5
Functions of microglia in the central nervous system--beyond the immune response.小胶质细胞在中枢神经系统中的功能——超越免疫反应。
Neuron Glia Biol. 2011 Feb;7(1):47-53. doi: 10.1017/S1740925X12000063. Epub 2012 May 22.
6
The effect of aged microglia on synaptic impairment and its relevance in neurodegenerative diseases.衰老小胶质细胞对突触损伤的影响及其在神经退行性疾病中的相关性。
Neurochem Int. 2021 Mar;144:104982. doi: 10.1016/j.neuint.2021.104982. Epub 2021 Feb 5.
7
Microglia Function in the Central Nervous System During Health and Neurodegeneration.健康与神经退行性变过程中中枢神经系统小胶质细胞的功能
Annu Rev Immunol. 2017 Apr 26;35:441-468. doi: 10.1146/annurev-immunol-051116-052358. Epub 2017 Feb 9.
8
Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease.在衰老、创伤性中枢神经系统损伤和神经退行性疾病中，小胶质细胞的预激活以及对二次损伤的反应性增强。
Neuropharmacology. 2015 Sep;96(Pt A):29-41. doi: 10.1016/j.neuropharm.2014.10.028. Epub 2014 Nov 13.
9
Sublime microglia: expanding roles for the guardians of the CNS.崇高的小胶质细胞：中枢神经系统守护者的扩展作用。
Cell. 2014 Jul 3;158(1):15-24. doi: 10.1016/j.cell.2014.06.008.
10
A friend in need may not be a friend indeed: role of microglia in neurodegenerative diseases.患难见真情：小胶质细胞在神经退行性疾病中的作用。
CNS Neurol Disord Drug Targets. 2013 Sep;12(6):726-40. doi: 10.2174/18715273113126660170.
引用本文的文献
1
Oseltamivir Phosphate Modulates CD24-Siglec-G/10 Interaction to Suppress Microglial-Driven Neuroinflammation After Cardiac Arrest.磷酸奥司他韦调节CD24-唾液酸结合免疫球蛋白样凝集素-G/10相互作用以抑制心脏骤停后小胶质细胞驱动的神经炎症。
CNS Neurosci Ther. 2025 Aug;31(8):e70495. doi: 10.1111/cns.70495.
2
G-protein coupled receptor kinase 2 mediates rheumatoid arthritis-induced depression-like behaviors via the hippocampal CRHR1 signaling pathway.G蛋白偶联受体激酶2通过海马促肾上腺皮质激素释放激素受体1信号通路介导类风湿关节炎诱发的抑郁样行为。
Acta Pharmacol Sin. 2025 Jul 21. doi: 10.1038/s41401-025-01621-8.
3
Microglia in the Rostral Ventromedial Medulla Mediate Synaptic Pruning via the C1q/C3-CR3 Signaling Pathway-A Mechanism for the Chronic Orofacial Pain.延髓头端腹内侧区的小胶质细胞通过C1q/C3-CR3信号通路介导突触修剪——一种慢性口面部疼痛的机制
Mol Neurobiol. 2025 Jun 13. doi: 10.1007/s12035-025-05109-8.
4
Chronic Stress Modulates Microglial Activation Dynamics, Shaping Priming Responses to Subsequent Stress.慢性应激调节小胶质细胞的激活动力学，塑造对后续应激的启动反应。
Brain Sci. 2025 May 21;15(5):534. doi: 10.3390/brainsci15050534.
5
The language of glioblastoma: A tale of cytokines and sex hormones communication.胶质母细胞瘤的语言：细胞因子与性激素交流的故事
Neurooncol Adv. 2025 Jan 25;7(1):vdaf017. doi: 10.1093/noajnl/vdaf017. eCollection 2025 Jan-Dec.
6
A Combination of 5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone and Curcumin Synergistically Reduces Neuroinflammation in Cortical Microglia by Targeting the NLRP3 Inflammasome and the NOX2/Nrf2 Signaling Pathway.5-(3',4'-二羟基苯基)-γ-戊内酯与姜黄素联合通过靶向NLRP3炎性小体和NOX2/Nrf2信号通路协同减轻皮质小胶质细胞中的神经炎症。
Nutrients. 2025 Apr 10;17(8):1316. doi: 10.3390/nu17081316.
7
Potential targets of microglia in the treatment of neurodegenerative diseases: Mechanism and therapeutic implications.小胶质细胞在神经退行性疾病治疗中的潜在靶点：机制与治疗意义
Neural Regen Res. 2026 Apr 1;21(4):1497-1511. doi: 10.4103/NRR.NRR-D-24-01343. Epub 2025 Mar 25.
8
Impact of Microglia-Derived Extracellular Vesicles on Resident Central Nervous System Cell Populations After Acute Brain Injury Under Various External Stimuli Conditions.不同外部刺激条件下，小胶质细胞衍生的细胞外囊泡对急性脑损伤后中枢神经系统常驻细胞群体的影响。
Mol Neurobiol. 2025 Mar 24. doi: 10.1007/s12035-025-04858-w.
9
Is the Relationship Between Adolescent Social Isolation and Anxiety-Like Behaviors Altered by Microglia Ablation in Female Long Evans Rats?在雌性Long Evans大鼠中，小胶质细胞消融是否会改变青少年社会隔离与焦虑样行为之间的关系？
Brain Behav. 2025 Mar;15(3):e70369. doi: 10.1002/brb3.70369.
10
Xiao-Chai-Hu-Tang Ameliorates Depressive Symptoms via Modulating Neuro-Endocrine Network in Chronic Unpredictable Mild Stress-Induced Mice.小柴胡汤通过调节慢性不可预测轻度应激诱导小鼠的神经内分泌网络改善抑郁症状。
CNS Neurosci Ther. 2025 Feb;31(2):e70290. doi: 10.1111/cns.70290.
本文引用的文献
1
The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques.阿尔茨海默病的主要风险因素：年龄、性别和基因调节小胶质细胞对 Aβ 斑块的反应。
Cell Rep. 2019 Apr 23;27(4):1293-1306.e6. doi: 10.1016/j.celrep.2019.03.099.
2
CARD9 microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment.CARD9 小胶质细胞通过 IL-1β 和 CXCL1 介导的中性粒细胞募集来促进抗真菌免疫。
Nat Immunol. 2019 May;20(5):559-570. doi: 10.1038/s41590-019-0377-2. Epub 2019 Apr 17.
3
Homozygous Mutations in CSF1R Cause a Pediatric-Onset Leukoencephalopathy and Can Result in Congenital Absence of Microglia.CSF1R 纯合突变可导致儿童起病的脑白质病，并可导致先天性小神经胶质细胞缺失。
Am J Hum Genet. 2019 May 2;104(5):936-947. doi: 10.1016/j.ajhg.2019.03.010. Epub 2019 Apr 11.
4
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains.CD22 阻断恢复衰老大脑中稳态小胶质细胞的吞噬作用。
Nature. 2019 Apr;568(7751):187-192. doi: 10.1038/s41586-019-1088-4. Epub 2019 Apr 3.
5
Microglial Phagocytosis of Newborn Cells Is Induced by Endocannabinoids and Sculpts Sex Differences in Juvenile Rat Social Play.内源性大麻素诱导小胶质细胞吞噬新生细胞，并塑造幼年大鼠社交玩耍的性别差异。
Neuron. 2019 Apr 17;102(2):435-449.e6. doi: 10.1016/j.neuron.2019.02.006. Epub 2019 Feb 28.
6
Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution.单细胞分辨率下的小鼠和人类小胶质细胞的时空异质性。
Nature. 2019 Feb;566(7744):388-392. doi: 10.1038/s41586-019-0924-x. Epub 2019 Feb 13.
7
Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing.深度单细胞 RNA 测序揭示小胶质细胞和脑髓系细胞的发育异质性。
Neuron. 2019 Jan 16;101(2):207-223.e10. doi: 10.1016/j.neuron.2018.12.006. Epub 2018 Dec 31.
8
Microglial cell loss after ischemic stroke favors brain neutrophil accumulation.缺血性脑卒中后小胶质细胞的丢失有利于脑中性粒细胞的聚集。
Acta Neuropathol. 2019 Feb;137(2):321-341. doi: 10.1007/s00401-018-1954-4. Epub 2018 Dec 22.
9
Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment.甲氨蝶呤化疗诱导持续的三胶质细胞失调，是化疗相关性认知障碍的基础。
Cell. 2019 Jan 10;176(1-2):43-55.e13. doi: 10.1016/j.cell.2018.10.049. Epub 2018 Dec 6.
10
Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes.单细胞 RNA 测序技术揭示了小鼠整个生命周期及损伤大脑中小胶质细胞的复杂细胞状态变化。
Immunity. 2019 Jan 15;50(1):253-271.e6. doi: 10.1016/j.immuni.2018.11.004. Epub 2018 Nov 21.
Zotero 插件