Jin Eun Hyo, Choi Yoon Jin, Lim Joo Hyun, Shin Cheol Min, Han Kyungdo, Lee Dong Ho
Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul 06236, Republic of Korea.
Center for Gastric Cancer, National Cancer Center, Goyang-si 10408, Gyeonggi-do, Republic of Korea.
J Clin Med. 2023 Jul 25;12(15):4889. doi: 10.3390/jcm12154889.
Metabolic syndrome (MetS) can be resolved through active control. We aimed to examine the effect of changes in MetS status on colorectal cancer (CRC) risk. A total of 5,704,611 Korean national insurance beneficiaries that received two consecutive biennial mandatory health exams (2009-2011) were followed-up until 2017. MetS was determined as the presence of at least three of five components. Participants were categorized into four groups according to the change in MetS status; MetS-never, -resolved, -developed, or -persistent. A Cox proportional hazards model adjusted for age, sex, smoking, alcohol drinking, and physical exercise was used. Participants who recovered from MetS had a higher risk of CRC than those free of MetS but had a lower risk than those with persistent MetS (HR: 0.91, 95% CI: 0.86-0.95 vs. HR: 0.75, 95% CI: 0.73-0.78; reference: persistence group). Among the five MetS components, resolving high blood pressure, abdominal obesity, and blood sugar had a preventive effect on CRC prevention, while normalization of lipid profile did not reduce CRC risk independently. Resolving MetS could reduce CRC risk compared to having persistent MetS, indicating the necessity of considering control of MetS as a CRC prevention policy.
代谢综合征（MetS）可通过积极控制得到缓解。我们旨在研究MetS状态变化对结直肠癌（CRC）风险的影响。对总共5704611名接受了连续两次两年一次强制性健康检查（2009 - 2011年）的韩国国民保险受益人进行随访，直至2017年。MetS被定义为存在五个组成部分中的至少三个。参与者根据MetS状态的变化分为四组：从未患MetS组、已缓解组、新发组或持续存在组。使用了经年龄、性别、吸烟、饮酒和体育锻炼调整的Cox比例风险模型。从MetS中恢复的参与者患CRC的风险高于未患MetS的参与者，但低于持续存在MetS的参与者（风险比：0.91，95%置信区间：0.86 - 0.95 对比 风险比：0.75，95%置信区间：0.73 - 0.78；参照组：持续存在组）。在五个MetS组成部分中，解决高血压、腹型肥胖和血糖问题对预防CRC有预防作用，而血脂谱正常化并不能独立降低CRC风险。与持续存在MetS相比，解决MetS可降低CRC风险，这表明有必要将控制MetS作为一项CRC预防政策来考虑。
