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小麦草和黑果腺肋花楸混合提取物在体外和体内抑制免疫球蛋白 E 介导的过敏反应。

Wheatgrass-and-Aronia-Mixed Extract Suppresses Immunoglobulin E-Mediated Allergic Reactions In Vitro and In Vivo.

机构信息

Department of Immunology, Jeonbuk National University Medical School, Jeonju-si 54907, Republic of Korea.

Department of Korean Pharmacy, Woosuk University, Wanju-Gun, Samnye-eup 55338, Republic of Korea.

出版信息

Int J Mol Sci. 2023 Jul 26;24(15):11979. doi: 10.3390/ijms241511979.

DOI:10.3390/ijms241511979
PMID:37569351
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10419027/
Abstract

Mast cells are an important component of immune responses. Immunoglobulin (Ig) E-sensitized mast cells release substances within minutes of allergen exposure, triggering allergic responses. Until now, numerous pharmacological effects of wheatgrass and aronia have been verified, but the effects of wheatgrass and aronia (TAAR)-mixed extract on allergic reactions have not been identified. Therefore, the aim of this study was to demonstrate the anti-allergic effect of TAAR extract on mast cell activation and cutaneous anaphylaxis. In this study, we investigated the anti-allergic effects and related mechanisms of TAAR extract in IgE-activated mast cells in vitro. We also assessed the ameliorating effect of TAAR extract on IgE-mediated passive cutaneous anaphylaxis mice in vivo. The TAAR extract significantly reduced the expression of β-hexosaminidase, histamine, and pro-inflammatory cytokines, which are mediators related to mast cell degranulation, via the regulation of various signaling pathways. The TAAR extract also regulated oxidative-stress-related factors through the Nrf2 signaling pathway. Additionally, treatment of TAAR extract to the passive cutaneous anaphylaxis mouse model improved ear thickness and local ear pigmentation. Taken together, our results suggest that TAAR extract is a potential candidate natural product to treat overall IgE-mediated allergic inflammation and oxidative-stress-related diseases by suppressing mast cell activity.

摘要

肥大细胞是免疫反应的重要组成部分。免疫球蛋白 (Ig) E 致敏的肥大细胞在过敏原暴露后的几分钟内释放物质，引发过敏反应。到目前为止，已经验证了小麦草和黑接骨木的许多药理学作用，但尚未确定小麦草和黑接骨木 (TAAR) 混合提取物对过敏反应的影响。因此，本研究旨在证明 TAAR 提取物对肥大细胞活化和皮肤过敏反应的抗过敏作用。在这项研究中，我们研究了 TAAR 提取物在体外 IgE 激活的肥大细胞中对过敏反应的影响及其相关机制。我们还评估了 TAAR 提取物对体内 IgE 介导的被动皮肤过敏反应小鼠的改善作用。TAAR 提取物通过调节各种信号通路，显著降低与肥大细胞脱颗粒相关的β-己糖胺酶、组胺和促炎细胞因子的表达。TAAR 提取物还通过 Nrf2 信号通路调节氧化应激相关因素。此外，用 TAAR 提取物治疗被动皮肤过敏反应小鼠模型可改善耳朵厚度和局部耳朵色素沉着。综上所述，我们的结果表明，TAAR 提取物通过抑制肥大细胞活性，是一种治疗整体 IgE 介导的过敏炎症和氧化应激相关疾病的潜在天然产物候选物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78bb/10419027/101ef3278df4/ijms-24-11979-g009.jpg
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Antioxidants (Basel). 2022 Dec 23;12(1):27. doi: 10.3390/antiox12010027.
2
Wheatgrass inhibits the lipopolysaccharide-stimulated inflammatory effect in RAW 264.7 macrophages.小麦草抑制脂多糖刺激的RAW 264.7巨噬细胞的炎症效应。
Curr Res Toxicol. 2021 Feb 23;2:116-127. doi: 10.1016/j.crtox.2021.02.005. eCollection 2021.
3
Medicinal plants from the 14 edition of the Russian Pharmacopoeia, recent updates.
俄罗斯药典第 14 版中的药用植物，最新更新。
J Ethnopharmacol. 2021 Mar 25;268:113685. doi: 10.1016/j.jep.2020.113685. Epub 2020 Dec 11.
4
Extract of Suppresses Mast Cell-Mediated Allergic Inflammation by Inhibiting Mitogen-Activated Protein Kinase and Nuclear Factor-κB.抑制丝裂原活化蛋白激酶和核因子-κB 抑制肥大细胞介导的过敏炎症。
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5
Chlorogenic Acid Alleviates Allergic Inflammatory Responses Through Regulating Th1/Th2 Balance in Ovalbumin-Induced Allergic Rhinitis Mice.绿原酸通过调节卵清蛋白诱导的变应性鼻炎小鼠 Th1/Th2 平衡缓解过敏炎症反应。
Med Sci Monit. 2020 Sep 1;26:e923358. doi: 10.12659/MSM.923358.
6
The polyphenol-rich extract from chokeberry ( L) modulates gut microbiota and improves lipid metabolism in diet-induced obese rats.来自黑果腺肋花楸（L）的富含多酚的提取物可调节饮食诱导的肥胖大鼠的肠道微生物群并改善脂质代谢。
Nutr Metab (Lond). 2020 Jul 7;17:54. doi: 10.1186/s12986-020-00473-9. eCollection 2020.
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9
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